Direct synthesis of dextran-coated superparamagnetic iron oxide nanoparticles in a capillary-based droplet reactor

被引：110

作者：

Kumar, Kritika ^{[2
]}

Nightingale, Adrian M. ^{[2
]}

Krishnadasan, Siva H. ^{[2
]}

Kamaly, Nazila ^{[2
]}

Wylenzinska-Arridge, Marzena ^{[2
]}

Zeissler, Katharina ^{[2
]}

Branford, Will R. ^{[2
]}

Ware, Ecaterina ^{[2
]}

deMello, Andrew J. ^{[1
]}

deMello, John C. ^{[2
]}

机构：

[1] ETH, Dept Chem & Appl Biosci, CH-8093 Zurich, Switzerland

[2] Univ London Imperial Coll Sci Technol & Med, London SW7 2AZ, England

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2012年 / 22卷 / 11期

基金：

英国工程与自然科学研究理事会;

关键词：

MAGNETIC NANOPARTICLES; MICROFLUIDIC SYNTHESIS; CONTRAST; ROUTES;

D O I：

10.1039/c2jm30257h

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We describe the controlled synthesis of dextran-coated superparamagnetic iron oxide nanoparticles (SPIONs) using a stable passively-driven capillary-based droplet reactor. High quality highly crystalline particles were obtained with a narrow size distribution of mean diameter 3.6 nm and standard deviation 0.8 nm. The particles were evaluated for use in MRI, and found to exhibit a large saturation magnetisation of 58 emu/g and a high T-2 relaxivity of 66 mM(-1)s(-1) at 4.7 T, signifying good MRI contrast enhancement properties.

引用

页码：4704 / 4708

页数：5

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