Sulfonated Carbon Catalyzed Biginelli Reaction for One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones and -thiones

被引：65

作者：

Moghaddas, Maryam ^{[1
]}

Davoodnia, Abolghasem ^{[1
]}

Heravi, Majid M. ^{[2
]}

Tavakoli-Hoseini, Niloofar ^{[1
]}

机构：

[1] Islamic Azad Univ, Dept Chem, Mashhad Branch, Mashhad, Iran

[2] Alzahra Univ, Dept Chem, Sch Sci, Tehran, Iran

来源：

CHINESE JOURNAL OF CATALYSIS | 2012年 / 33卷 / 04期

关键词：

sulfonated carbon; solid acid; Biginelli reaction; heterogeneous catalysis; solvent-free condition; SOLVENT-FREE CONDITIONS; ACIDIC IONIC LIQUID; REUSABLE CATALYST; SOLID ACID; 1,2,4,5-TETRASUBSTITUTED IMIDAZOLES; 12-TUNGSTOPHOSPHORIC ACID; EFFICIENT; DIHYDROPYRIMIDINONES; DERIVATIVES; GREEN;

D O I：

10.1016/S1872-2067(11)60377-X

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A sulfonated carbon material was shown to be a highly efficient, eco-friendly, and recyclable solid acid catalyst for the Biginelli reaction of beta-ketoester, aldehyde, and urea or thiourea under solvent-free conditions. It gave 3,4-dihydropyrimidin-2(1H)-ones and -thiones in good to excellent yields. This method has the advantages of a simple procedure with easy work-up, short reaction time, and high yields. The catalyst can be recycled after a simple work-up and was reused four times without substantial reduction in activity.

引用

页码：706 / 710

页数：5

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