Tiliroside Isolated from Agrimonia pilosa Ledeb.: Enhanced Adiponectin Secretion and GLUT4 Translocation in 3T3-L1 Cells

被引：0

作者：

Song, Li L. ^{[1
]}

Li, Dong ^{[1
]}

Zhang, Mi X. ^{[2
]}

Zhuang, Peng W. ^{[2
]}

Yan, Zhe L. ^{[2
]}

Li, Jin N. ^{[1
]}

Deng, Yan R. ^{[1
]}

Zhang, Yan J. ^{[2
]}

机构：

[1] Tianjin Univ Tradit Chinese Med, Coll Tradit Chinese Med, Tianjin 300193, Peoples R China

[2] Tianjin Univ Tradit Chinese Med, Tianjin Key Lab Chem & Anal Chinese Mat Med, Tianjin 300193, Peoples R China

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2013年 / 32卷 / 04期

关键词：

Adiponectin secretion; Agrimonia pilosa Ledeb; 3T3-L1; cells; GLUT4; Isolation of tiliroside; Translocation; HORMONE ADIPONECTIN; INSULIN; FLAVONOIDS; TISSUES;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Three kinds of insulin resistance cell models were used to. study how Agrimonia pilosa Ledeb (AP) extracts affect glucose uptake in cells. One flavone glycoside, tiliroside, was isolated from AP by bioassay-guided chromatographic fractionation and tested it on promoting glucose uptake. Adipocytes were used to identify the response of tiliroside on insulin resistance related mRNA expression. It was found that glucose transporter factor 4GLUT4 translocation and the number of IR were enhanced by tiliroside treatment. Our findings indicate that tiliroside from AP may be beneficial for diabetic complications through its enhanced adiponectin secretion and GLUT4 translocation.

引用

页码：524 / 530

页数：7

共 32 条

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