SARS-CoV-2 infection of the placenta

被引：358

作者：

Hosier, Hillary ^{[1
]}

Farhadian, Shelli F. ^{[2
]}

Morotti, Raffaella A. ^{[3
]}

Deshmukh, Uma ^{[1
]}

Lu-Culligan, Alice ^{[4
]}

Campbell, Katherine H. ^{[1
]}

Yasumoto, Yuki ^{[5
]}

Vogels, Chantal B. F. ^{[6
]}

Casanovas-Massana, Arnau ^{[6
]}

Vijayakumar, Pavithra ^{[1
]}

Geng, Bertie ^{[1
]}

Odio, Camila D. ^{[2
]}

Fournier, John ^{[2
]}

Brito, Anderson F. ^{[6
]}

Fauver, Joseph R. ^{[6
]}

Liu, Feimei ^{[4
]}

Alpert, Tara ^{[7
]}

Tal, Reshef ^{[1
]}

Szigeti-Buck, Klara ^{[3
]}

Perincheri, Sudhir ^{[3
]}

Larsen, Christopher ^{[8
]}

Gariepy, Aileen M. ^{[1
]}

Aguilar, Gabriela ^{[1
]}

Fardelmann, Kristen L. ^{[9
]}

Harigopal, Malini ^{[3
]}

Taylor, Hugh S. ^{[1
]}

Pettker, Christian M. ^{[1
]}

Wyllie, Anne L. ^{[6
]}

Dela Cruz, Charles ^{[10
]}

Ring, Aaron M. ^{[4
]}

Grubaugh, Nathan D. ^{[6
]}

Ko, Albert, I ^{[6
]}

Horvath, Tamas L. ^{[5
]}

Iwasaki, Akiko ^{[4
]}

Reddy, Uma M. ^{[1
]}

Lipkind, Heather S. ^{[1
]}

机构：

[1] Yale Sch Med, Dept Obstet Gynecol & Reprod Sci, New Haven, CT USA

[2] Yale Sch Med, Sect Infect Dis, Dept Med, New Haven, CT USA

[3] Yale Sch Med, Dept Pathol, New Haven, CT USA

[4] Yale Sch Med, Dept Immunobiol, New Haven, CT USA

[5] Yale Sch Med, Dept Comparat Med, New Haven, CT USA

[6] Yale Sch Publ Hlth, Dept Epidemiol Microbial Dis, New Haven, CT USA

[7] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT USA

[8] Arkana Labs, Little Rock, AR USA

[9] Yale Univ, Dept Anesthesiol, Yale Sch Med, New Haven, CT USA

[10] Yale Univ, Dept Med, Sect Pulm & Crit Care Med, Yale Sch Med, New Haven, CT 06520 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2020年 / 130卷 / 09期

关键词：

CHRONIC INTERVILLOSITIS; CHORIONIC VILLI; MALARIA;

D O I：

10.1172/JCI139569

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

BACKGROUND. The effects of the novel coronavirus disease 2019 (COVID-19) in pregnancy remain relatively unknown. We present a case of second trimester pregnancy with symptomatic COVID-19 complicated by severe preeclampsia and placental abruption. METHODS. We analyzed the placenta for the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through molecular and immunohistochemical assays and by and electron microscopy and measured the maternal antibody response in the blood to this infection. RESULTS. SARS-CoV-2 localized predominantly to syncytiotrophoblast cells at the materno-fetal interface of the placenta. Histological examination of the placenta revealed a dense macrophage infiltrate, but no evidence for the vasculopathy typically associated with preeclampsia. CONCLUSION. This case demonstrates SARS-CoV-2 invasion of the placenta, highlighting the potential for severe morbidity among pregnant women with COVID-19.

引用

页码：4947 / 4953

页数：7

共 28 条

[1]

Amanat F, 2020, NAT MED, V26, P1033, DOI [10.1038/s41591-020-0913-5, 10.1101/2020.03.17.20037713]

[2] Activation of local chorionic villi angiotensin II levels but not angiotensin (1-7) in preeclampsia [J].

Anton, Lauren ;

Merrill, David C. ;

Neves, Liomar A. A. ;

Stovall, Kathryn ;

Gallagher, Patricia E. ;

Diz, Debra I. ;

Moorefield, Cheryl ;

Gruver, Courtney ;

Ferrario, Carlos M. ;

Brosnihan, K. Bridget .

HYPERTENSION, 2008, 51 (04) :1066-1072

[3] Second-Trimester Miscarriage in a Pregnant Woman With SARS-CoV-2 Infection [J].

Baud, David ;

Greub, Gilbert ;

Favre, Guillaume ;

Gengler, Carole ;

Jaton, Katia ;

Dubruc, Estelle ;

Pomar, Leo .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (21) :2198-2200

[4] Clinical outcomes in chronic intervillositis of unknown etiology [J].

Bos, M. ;

Harris-Mostert, E. T. M. S. ;

van der Meeren, L. E. ;

Baelde, J. J. ;

Williams, D. J. ;

Nikkels, P. G. J. ;

Bloemenkamp, K. W. M. ;

van der Hoorn, M. L. P. .

PLACENTA, 2020, 91 :19-23

[5]

BRESLIN N, 2020, AM J OBST GYNEC MFM, V2, DOI DOI 10.1016/J.AJOGMF.2020.100118

[6] Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records [J].

Chen, Huijun ;

Guo, Juanjuan ;

Wang, Chen ;

Luo, Fan ;

Yu, Xuechen ;

Zhang, Wei ;

Li, Jiafu ;

Zhao, Dongchi ;

Xu, Dan ;

Gong, Qing ;

Liao, Jing ;

Yang, Huixia ;

Hou, Wei ;

Zhang, Yuanzhen .

LANCET, 2020, 395 (10226) :809-815

[7]

Fauver Joseph R, 2020, medRxiv, DOI 10.1101/2020.03.25.20043828

[8]

Freitag L, 2013, INT J CLIN EXP PATHO, V6, P1103

[9] A statistically defined endpoint titer determination method for Immunoassays [J].

Frey, A ;

Di Canzio, J ;

Zurakowski, D .

JOURNAL OF IMMUNOLOGICAL METHODS, 1998, 221 (1-2) :35-41

[10]

Goldsmith CS, TRANSMISSION ELECT M

← 1 2 3 →