B-Raf mutation: A key player in molecular biology of cancer

被引：60
作者：
Rahman, M. A. [1 ]
Salajegheh, A. [1 ]
Smith, R. A. [1 ]
Lam, A. K. -Y. [1 ]
机构：
[1] Griffith Univ, Griffith Hlth Inst, Canc Mol Pathol Grp, Gold Coast, Qld, Australia
来源：
EXPERIMENTAL AND MOLECULAR PATHOLOGY | 2013年 / 95卷 / 03期
关键词：
B-Raf; BRAF; Mutation; Melanoma; Colorectal cancer; Thyroid cancer; NF-KAPPA-B; PAPILLARY THYROID-CARCINOMA; ENDOTHELIAL-GROWTH-FACTOR; CELL-CYCLE ARREST; SIGNAL-REGULATED KINASE; CPG ISLAND METHYLATION; BRAF MUTATION; MELANOCORTIN-1; RECEPTOR; CLINICOPATHOLOGICAL RELEVANCE; TRANSCRIPTIONAL REGULATION;
D O I：
10.1016/j.yexmp.2013.10.005
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
B-Raf is one of the more commonly mutated proto-oncogenes implicated in the development of cancers. In this review, we consider the mechanisms and clinical impacts of B-Raf mutations in cancer and discuss the implications for the patient in melanoma, thyroid cancer and colorectal cancer, where B-Raf mutations are particularly common. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：336 / 342
页数：7
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