B-Raf mutation: A key player in molecular biology of cancer

被引：60

作者：

Rahman, M. A. ^{[1
]}

Salajegheh, A. ^{[1
]}

Smith, R. A. ^{[1
]}

Lam, A. K. -Y. ^{[1
]}

机构：

[1] Griffith Univ, Griffith Hlth Inst, Canc Mol Pathol Grp, Gold Coast, Qld, Australia

来源：

EXPERIMENTAL AND MOLECULAR PATHOLOGY | 2013年 / 95卷 / 03期

关键词：

B-Raf; BRAF; Mutation; Melanoma; Colorectal cancer; Thyroid cancer; NF-KAPPA-B; PAPILLARY THYROID-CARCINOMA; ENDOTHELIAL-GROWTH-FACTOR; CELL-CYCLE ARREST; SIGNAL-REGULATED KINASE; CPG ISLAND METHYLATION; BRAF MUTATION; MELANOCORTIN-1; RECEPTOR; CLINICOPATHOLOGICAL RELEVANCE; TRANSCRIPTIONAL REGULATION;

D O I：

10.1016/j.yexmp.2013.10.005

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

B-Raf is one of the more commonly mutated proto-oncogenes implicated in the development of cancers. In this review, we consider the mechanisms and clinical impacts of B-Raf mutations in cancer and discuss the implications for the patient in melanoma, thyroid cancer and colorectal cancer, where B-Raf mutations are particularly common. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：336 / 342

页数：7

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