The Hippo Signaling Pathway in the Regulation of Skeletal Muscle Mass and Function

被引：64

作者：

Watt, Kevin I. ^{[1
,2
,3
]}

Goodman, Craig A. ^{[4
,5
,6
]}

Hornberger, Troy A. ^{[7
]}

Gregorevic, Paul ^{[8
,9
,10
]}

机构：

[1] Baker Heart & Diabet Inst, Melbourne, Vic, Australia

[2] Monash Univ, Dept Diabet, Clayton, Vic, Australia

[3] Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA

[4] Victoria Univ, Coll Hlth & Biomed, Melbourne, Vic, Australia

[5] Victoria Univ, ISEAL, Melbourne, Vic, Australia

[6] Victoria Univ, Australian Inst Musculoskeletal Sci AIMSS, St Albans, Vic, Australia

[7] Univ Wisconsin, Dept Comparat Biosci, 2015 Linden Dr W, Madison, WI 53706 USA

[8] Univ Melbourne, Dept Physiol, Melbourne, Vic, Australia

[9] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic, Australia

[10] Univ Washington, Sch Med, Dept Neurol, Seattle, WA USA

来源：

EXERCISE AND SPORT SCIENCES REVIEWS | 2018年 / 46卷 / 02期

基金：

美国国家卫生研究院; 英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

hippo signaling pathway; yes-associated protein (Yap); transcriptional co-activator with PDZ-binding motif (Taz); skeletal muscle; exercise-induced hypertrophy; CELL-PROLIFERATION; PROMOTES APOPTOSIS; EMBRYONAL RHABDOMYOSARCOMA; MYOGENIC DIFFERENTIATION; RESISTANCE EXERCISE; SATELLITE CELLS; GROWTH-CONTROL; TISSUE-GROWTH; YAP; TAZ;

D O I：

10.1249/JES.0000000000000142

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The Hippo signaling pathway regulates the activity of the proteins Yes-associated protein (Yap) and transcriptional co-activator with PDZ-binding motif (Taz) to control tissue growth in many different cell types. Previously, we demonstrated that Yap is a critical regulator of skeletal muscle mass. We hypothesize that alterations in Yap and Taz activity modulate the anabolic adaptations of skeletal muscle to resistance exercise.

引用

页码：92 / 96

页数：5

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