Indicted: Worms caught using steroids

被引：24

作者：

Beckstead, RB ^{[1
]}

Thummell, CS ^{[1
]}

机构：

[1] Univ Utah, Sch Med, Howard Hughes Med Inst, Dept Human Genet, Salt Lake City, UT 84112 USA

来源：

CELL | 2006年 / 124卷 / 06期

关键词：

D O I：

10.1016/j.cell.2006.03.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three recent papers provide new insights into endocrinology in the worm Caenorhabditis elegans. These studies identify natural steroid ligands for the DAF-12 nuclear receptor, define a new enzyme in the hormone biosynthetic pathway, and clarify the role of endocrine signaling in adult longevity.

引用

页码：1137 / 1140

页数：4

共 17 条

[1] Antebi A, 2000, GENE DEV, V14, P1512
[2] Germ-cell loss extends C-elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling
Berman, JR
Kenyon, C
[J]. CELL, 2006, 124 (05) : 1055 - 1068
[3] Hormonal signals produced by DAF-9/cytochrome P450 regulate C-elegans dauer diapause in response to environmental cues
Gerisch, B
Antebi, A
[J]. DEVELOPMENT, 2004, 131 (08): : 1765 - 1776
[4] A hormonal signaling pathway influencing C-elegans metabolism, reproductive development, and life span
Gerisch, B
Weitzel, C
Kober-Eisermann, C
Rottiers, V
Antebi, A
[J]. DEVELOPMENTAL CELL, 2001, 1 (06) : 841 - 851
[5] Lipophilic regulator of a developmental switch in Caenorhabditis elegans
Gill, MS
Held, JM
Fisher, AL
Gibson, BW
Lithgow, GJ
[J]. AGING CELL, 2004, 3 (06) : 413 - 421
[6] Signals from the reproductive system regulate the lifespan of C-elegans
Hsin, H
Kenyon, C
[J]. NATURE, 1999, 399 (6734) : 362 - 366
[7] Jia KL, 2002, DEVELOPMENT, V129, P221
[8] The plasticity of aging: Insights from long-lived mutants
Kenyon, C
[J]. CELL, 2005, 120 (04) : 449 - 460
[9] Less steroids make bigger flies
King-Jones, K
Thummel, CS
[J]. SCIENCE, 2005, 310 (5748) : 630 - 631
[10] Tissue-specific activities of C-elegans DAF-16 in the regulation of lifespan
Libina, N
Berman, JR
Kenyon, C
[J]. CELL, 2003, 115 (04) : 489 - 502

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