Relationship between plasma mid-regional pro-adrenomedullin level and resistance to antihypertensive therapy in stable kidney transplant recipients

被引：6

作者：

Suzuki, Yosuke ^{[1
]}

Itoh, Hiroki ^{[1
]}

Katagiri, Fumihiko ^{[2
]}

Sato, Fuminori ^{[3
]}

Kawasaki, Kanako ^{[1
]}

Sato, Yukie ^{[1
]}

Sato, Yuhki ^{[1
]}

Mimata, Hiromitsu ^{[3
]}

Takeyama, Masaharu ^{[1
]}

机构：

[1] Oita Univ Hosp, Dept Clin Pharm, Oita 8795593, Japan

[2] Tokyo Univ Pharm & Life Sci, Lab Clin Biochem, Hachioji, Tokyo 1920392, Japan

[3] Oita Univ, Fac Med, Dept Urol, Oita 8795593, Japan

来源：

PEPTIDES | 2013年 / 48卷

关键词：

MIDREGIONAL PROADRENOMEDULLIN; CIRCULATING ADRENOMEDULLIN; PEPTIDE; DISEASE; HYPERTENSION; PROTEIN; SEPSIS;

D O I：

10.1016/j.peptides.2013.08.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the relationship between plasma mid-regional pro-adrenomedullin (MR-proADM)-like immunoreactive substance (IS) level and clinical characteristics associated with renal failure or resistance to antihypertensive therapy in stable kidney transplant recipients. Forty-six Japanese kidney transplant recipients who underwent transplantation more than 90 days prior to the study were included. To evaluate resistance to antihypertensive therapy, we calculated the treatment intensity score of the antihypertensive drugs in each recipient. Morning blood samples were collected and plasma MR-proADM-IS levels were measured using an enzyme immunoassay. A significant correlation was observed between plasma MR-proADM-IS level with creatinine clearance or treatment intensity score. Multiple regression analysis identified plasma MR-proADM level and body mass index as significant independent factors associated with treatment intensity score. Plasma MR-proADM level may be a useful biomarker indicating the degree of resistance to antihypertensive therapy. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：45 / 48

页数：4

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