Independent and combined effects of environmental factors and miR-126, miR-143, and miR-145 on the risk of coronary heart disease

被引:12
作者
Lin, Da-Cen [1 ]
Lin, Jia-Bing [1 ]
Chen, Zhou [2 ]
Chen, Rong [1 ]
Wan, Chun-Yu [1 ]
Lin, Shao-Wei [1 ]
Ruan, Qi-Shuang [3 ]
Li, Huang-Yuan [4 ]
Wu, Si-Ying [1 ]
机构
[1] Fujian Med Univ, Dept Epidemiol & Hlth Stat, Key Lab Environm & Hlth Univ & Coll Fujian, Sch Publ Hlth, Fuzhou, Fujian, Peoples R China
[2] Fujian Univ Tradit Chinese Med, Affiliated Peoples Hosp, Fuzhou, Fujian, Peoples R China
[3] Fujian Med Univ, Union Hosp, Fuzhou, Fujian, Peoples R China
[4] Fujian Med Univ, Sch Publ Hlth, Dept Prevent Med, Fujian Prov Key Lab Environm Factors & Canc, Fuzhou, Fujian, Peoples R China
关键词
Case-control study; Coronary heart disease; Environmental factors; Gene-environment interaction; MiR-126; MiR-143; MiR-145; CIRCULATING MICRORNAS; EXPRESSION; BIOMARKERS; CELLS;
D O I
10.11909/j.issn.1671-5411.2017.11.004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective To evaluate the effects of environmental factors and microRNAs (miRNAs) (miR-126, miR-143, and miR-145) on the risk of coronary heart disease (CHD). Methods A frequency-matched case-control study (450 patients, 450 controls) was conducted from April 2014 to December 2016 in Fuzhou City, China. Environmental factors were investigated using a self-administered questionnaire, and the expression levels of miR-126, miR-143, and miR-145 were determined by quantitative real-time Polymerase Chain Reaction (PCR) in peripheral blood mononuclear cells. Unconditional logistic regression models were used for statistical evaluation. Results Alcohol consumption, high-salt diets, high-intensity work, and lack of physical activity were significantly associated with increased CHD risk, whereas light diet was significantly associated with decreased risk. MiR-126, miR-143, and miR-145 were highly expressed in the CHD group compared with the control group. After adjustment for other environmental factors, unconditional logistic regression results revealed that miR-126, miR-143, and depression were the independent risk factors of CHD, and light diet was the independent protective factor of CHD. Conclusions Our data suggest that a family history of CHD, anxiety, and alcohol consumption was significantly associated with increased CHD risk, whereas light diet was significantly associated with decreased risk. Furthermore, miR-126 and miR-143 in combination with several risk factors, could play a joint role in the development of CHD. Therefore, it is necessary to manage patients with CHD in all directions and multiple level.
引用
收藏
页码:688 / 695
页数:8
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