Design, synthesis, and biological evaluation of a novel anticancer agent ON 015640 with tubulin depolymerizing activity

被引:0
|
作者
Mallireddigari, Muralidhar R. [3 ]
Pallela, Venkat R. [3 ]
Hoffman, Benjamin S. [3 ]
Bharathi, Vijaya [1 ]
Akula, Balaiah [3 ]
Cosenza, Stephen C. [2 ]
Reddy, E. Premkumar [2 ]
Reddy, M. V. Ramana [1 ]
机构
[1] Mt Sinai Sch Med, Dept Struct & Chem Biol, New York, NY 10029 USA
[2] Mt Sinai Sch Med, Dept Oncol Sci, New York, NY 10029 USA
[3] Onconova Therapeut Inc, Dept Med Chem, Newtown, PA 18940 USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
67-MEDI
引用
收藏
页数:1
相关论文
共 50 条
  • [41] Design, synthesis and antitubulin activity of novel podophyllotoxin derivatives as potent anticancer agent
    Lifei Bai
    Renlei Wang
    Ye Zou
    Guohua Xu
    Chemical Research in Chinese Universities, 2015, 31 : 964 - 969
  • [42] Design, Synthesis, and Biological Evaluation of Stable Colchicine Binding Site Tubulin Inhibitors as Potential Anticancer Agents
    Lu, Yan
    Chen, Jianjun
    Wang, Jin
    Li, Chien-Ming
    Ahn, Sunjoo
    Barrett, Christina M.
    Dalton, James T.
    Li, Wei
    Miller, Duane D.
    JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (17) : 7355 - 7366
  • [43] Design, synthesis, and biological evaluation of diaryl heterocyclic derivatives targeting tubulin polymerization with potent anticancer activities
    Li, Gang
    Wu, Jia-Qiang
    Cai, Xiaojia
    Guan, Wen
    Zeng, Zhijun
    Ou, Yanghui
    Wu, Xiaoyun
    Li, Jiayu
    Fang, Xiangxiang
    Liu, Jinling
    Zhang, Yali
    Wang, Huamin
    Yin, Canqiang
    Yao, Hongliang
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 252
  • [44] Novel resveratrol smart lipids; design, formulation, and biological evaluation of anticancer activity
    Diab, Reem Fekry
    Abdelghany, Tamer M.
    Gad, Shadeed
    Elbakry, Asmaa M.
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 2024, 76 (06) : 631 - 645
  • [45] Design, synthesis, and biological evaluation of novel 5,6,7-trimethoxy quinolines as potential anticancer agents and tubulin polymerization inhibitors
    Mirzaei, Salimeh
    Eisvand, Farhad
    Hadizadeh, Farzin
    Mosaffa, Fatemeh
    Ghodsi, Razieh
    IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2020, 23 (12) : 1527 - 1537
  • [46] Design, Synthesis, and Biological Evaluation of Combretabenzodiazepines: A Novel Class of Anti-Tubulin Agents
    Galli, Ubaldina
    Travelli, Cristina
    Aprile, Silvio
    Arrigoni, Elena
    Torretta, Simone
    Grosa, Giorgio
    Massarotti, Alberto
    Sorba, Giovanni
    Canonico, Pier Luigi
    Genazzani, Armando A.
    Tron, Gian Cesare
    JOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (03) : 1345 - 1357
  • [47] Design, synthesis and biological evaluation of novel macrocyclic bisbibenzyl analogues as tubulin polymerization inhibitors
    Sun, Bin
    Li, Lin
    Hu, Qing-wen
    Xie, Fei
    Zheng, Hong-bo
    Niu, Huan-min
    Yuan, Hui-qing
    Lou, Hong-xiang
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 121 : 484 - 499
  • [48] Design, Synthesis and biological evaluation of the novel antitumor agent aurone derivatives
    Guo, QianNan
    Iv, Lei
    Zhou, Yao
    Yu, Peng
    Teng, Yuou
    ADVANCES IN CHEMICAL ENGINEERING III, PTS 1-4, 2013, 781-784 : 1235 - +
  • [49] Design, synthesis and biological evaluation of arylcinnamide hybrid derivatives as novel anticancer agents
    Romagnoli, Romeo
    Baraldi, Pier Giovanni
    Salvador, Maria Kimatrai
    Chayah, Mariem
    Camacho, M. Encarnacion
    Prencipe, Filippo
    Hamel, Ernest
    Consolaro, Francesca
    Basso, Giuseppe
    Viola, Giampietro
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 81 : 394 - 407
  • [50] Design, synthesis and biological evaluation of novel sesquiterpene mustards as potential anticancer agents
    Xu, Yuan-Zhen
    Cu, Xue-Yan
    Peng, Shou-Jiao
    Fang, Jian-Guo
    Zhang, Ying-Mei
    Huang, De-Jun
    Chen, Jian-Jun
    Gao, Kun
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 94 : 284 - 297