Reversing Type 2 Diabetes: A Narrative Review of the Evidence

被引：104

作者：

Hallberg, Sarah J. ^{[1
,2
,3
]}

Gershuni, Victoria M. ^{[4
]}

Hazbun, Tamara L. ^{[2
,3
]}

Athinarayanan, Shaminie J. ^{[1
]}

机构：

[1] Virta Hlth, 535 Mission St, San Francisco, CA 94105 USA

[2] Indiana Univ Hlth Arnett, Lafayette, IN 47904 USA

[3] Indiana Univ Sch Med, Indianapolis, IN 46202 USA

[4] Univ Penn, Perelman Sch Med, Dept Surg, Philadelphia, PA 19104 USA

来源：

NUTRIENTS | 2019年 / 11卷 / 04期

关键词：

diabetes; diabetes reversal; bariatric surgery; very-low-calorie; low-carbohydrate; LOW-CARBOHYDRATE-DIET; CARDIOVASCULAR RISK-FACTORS; LOW-FAT DIET; LOW-CALORIE DIET; RESTRICTED LOW-CARBOHYDRATE; INTENSIVE MEDICAL THERAPY; LIFE-STYLE INTERVENTION; WEIGHT-LOSS DIETS; Y GASTRIC BYPASS; BARIATRIC SURGERY;

D O I：

10.3390/nu11040766

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: Type 2 diabetes (T2D) has long been identified as an incurable chronic disease based on traditional means of treatment. Research now exists that suggests reversal is possible through other means that have only recently been embraced in the guidelines. This narrative review examines the evidence for T2D reversal using each of the three methods, including advantages and limitations for each. Methods: A literature search was performed, and a total of 99 original articles containing information pertaining to diabetes reversal or remission were included. Results: Evidence exists that T2D reversal is achievable using bariatric surgery, low-calorie diets (LCD), or carbohydrate restriction (LC). Bariatric surgery has been recommended for the treatment of T2D since 2016 by an international diabetes consensus group. Both the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) now recommend a LC eating pattern and support the short-term use of LCD for weight loss. However, only T2D treatment, not reversal, is discussed in their guidelines. Conclusion: Given the state of evidence for T2D reversal, healthcare providers need to be educated on reversal options so they can actively engage in counseling patients who may desire this approach to their disease.

引用

页码：1 / 16

页数：17

共 117 条

[41] Long-term effects of a diet loosely restricting carbohydrates on HbA1c levels, BMI and tapering of sulfonylureas in type 2 diabetes: A 2-year follow-up study [J].

Haimoto, Hajime ;

Iwata, Mitsunaga ;

Wakai, Kenji ;

Umegaki, Hiroyuki .

DIABETES RESEARCH AND CLINICAL PRACTICE, 2008, 79 (02) :350-356

[42] Effectiveness and Safety of a Novel Care Model for the Management of Type 2 Diabetes at 1 Year: An Open-Label, Non-Randomized, Controlled Study [J].

Hallberg, Sarah J. ;

McKenzie, Amy L. ;

Williams, Paul T. ;

Bhanpuri, Nasir H. ;

Peters, Anne L. ;

Campbell, Wayne W. ;

Hazbun, Tamara L. ;

Volk, Brittanie M. ;

McCarter, James P. ;

Phinney, Stephen D. ;

Volek, Jeff S. .

DIABETES THERAPY, 2018, 9 (02) :583-612

[43] Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and improves myocardial function [J].

Hammer, Sebastiaan ;

Snel, Marieke ;

Lamb, Hildo J. ;

Jazet, Ingrid M. ;

van der Meer, Rutger W. ;

Pijl, Hanno ;

Meinders, Edo A. ;

Romijn, Johannes A. ;

de Roos, Albert ;

Smit, Johannes W. A. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 52 (12) :1006-1012

[44] Insulin Therapy in People With Type 2 Diabetes: Opportunities and Challenges? [J].

Home, Philip ;

Riddle, Matthew ;

Cefalu, William T. ;

Bailey, Clifford J. ;

Bretzel, Reinhard G. ;

del Prato, Stefano ;

Leroith, Derek ;

Schernthaner, Guntram ;

van Gaal, Luc ;

Raz, Itamar .

DIABETES CARE, 2014, 37 (06) :1499-1508

[45] EFFECTS OF CALORIC RESTRICTION AND WEIGHT-LOSS ON GLYCEMIC CONTROL, INSULIN RELEASE AND RESISTANCE, AND ATHEROSCLEROTIC RISK IN OBESE PATIENTS WITH TYPE-II DIABETES-MELLITUS [J].

HUGHES, TA ;

GWYNNE, JT ;

SWITZER, BR ;

HERBST, C ;

WHITE, G .

AMERICAN JOURNAL OF MEDICINE, 1984, 77 (01) :7-17

[46] Effect of low-calorie versus low-carbohydrate ketogenic diet in type 2 diabetes [J].

Hussain, Talib A. ;

Mathew, Thazhumpal C. ;

Dashti, Ali A. ;

Asfar, Sami ;

Al-Zaid, Naji ;

Dashti, Hussein M. .

NUTRITION, 2012, 28 (10) :1016-1021

[47]

International Diabetes Federation, 2017, IDF Diabetes Atlas, V8th ed.

[48] Effects of a Low-intensity Intervention That Prescribed a Low-carbohydrate vs. a Low-fat Diet in Obese, Diabetic Participants [J].

Iqbal, Nayyar ;

Vetter, Marion L. ;

Moore, Renee H. ;

Chittams, Jesse L. ;

Dalton-Bakes, Cornelia V. ;

Dowd, Monique ;

Williams-Smith, Catherine ;

Cardillo, Serena ;

Wadden, Thomas A. .

OBESITY, 2010, 18 (09) :1733-1738

[49] Beneficial effects of a Paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomized cross-over pilot study [J].

Jonsson, Tommy ;

Granfeldt, Yvonne ;

Ahren, Bo ;

Branell, Ulla-Carin ;

Palsson, Gunvor ;

Hansson, Anita ;

Soderstrom, Margareta ;

Lindeberg, Staffan .

CARDIOVASCULAR DIABETOLOGY, 2009, 8

[50] Incidence of Remission in Adults With Type 2 Diabetes: The Diabetes & Aging Study [J].

Karter, Andrew J. ;

Nundy, Shantanu ;

Parker, Melissa M. ;

Moffet, Howard H. ;

Huang, Elbert S. .

DIABETES CARE, 2014, 37 (12) :3188-3195

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