The Role of Extrapleural Pneumonectomy in Malignant Pleural Mesothelioma

被引：3

作者：

Donahoe, Laura L. ^{[1
]}

de Perrot, Marc ^{[2
]}

机构：

[1] Univ Hlth Network, Toronto Gen Hosp, Princess Margaret Canc Ctr, Div Thorac Surg, Toronto, ON, Canada

[2] Univ Hlth Network, Toronto Gen Hosp, Princess Margaret Canc Ctr, Mesothelioma Program,Div Thorac Surg, 9N-961, Toronto, ON M5G 2C4, Canada

来源：

THORACIC SURGERY CLINICS | 2020年 / 30卷 / 04期

关键词：

Mesothelioma; Extrapleural pneumonectomy; Surgery; Multimodality therapy; DOSE HEMITHORACIC RADIATION; CANCER-DIRECTED SURGERY; PHASE-II TRIAL; TRIMODALITY THERAPY; CISPLATIN; MULTICENTER; CHEMOTHERAPY; FEASIBILITY; PLEURECTOMY/DECORTICATION; IMMUNOTHERAPY;

D O I：

10.1016/j.thorsurg.2020.08.004

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Extrapleural pneumonectomy (EPP) is the most extensive form of surgery for mesothelioma, involving en bloc resection of visceral and parietal pleura, lung, diaphragm and pericardium, with reconstruction of the pericardium and diaphragm. It can be performed safely in carefully selected patients. It should be performed in experienced centers as part of a multimodality treatment plan. The SMART approach, with a short course of induction hemithoracic radiation followed by EPP has demonstrated safety and value of hypofractionated hemithoracic radiation combined with complete macroscopic resection. We are conducting a clinical trial with oligofractionated hemithoracic radiation in early-stage mesothelioma.

引用

页码：461 / +

页数：12

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