Nasopharyngeal Pneumococcal Carriage in Nigeria: a two-site, population-based survey

被引：25

作者：

Adetifa, Ifedayo M. O. ^{[1
,2
,3
]}

Adamu, Aishatu L. ^{[4
]}

Karani, Angela ^{[2
]}

Waithaka, Michael ^{[2
]}

Odeyemi, Kofo A. ^{[5
]}

Okoromah, Christy A. N. ^{[3
]}

Bello, Mohammed M. ^{[4
]}

Abubakar, Isa S. ^{[4
]}

Inem, Victor ^{[5
]}

Scott, J. Anthony. G. ^{[1
,2
]}

机构：

[1] London Sch Hyg & Trop Med, Dept Infect Dis Epidemiol, London WC1E 7HT, England

[2] KEMRI Wellcome Trust Res Programme, Dept Epidemiol & Demog, POB 230-80108, Kilifi, Kenya

[3] Lagos Univ, Univ Lagos, Coll Med, Teaching Hosp,Dept Paediat & Child Hlth, PMB 12003, Lagos, Nigeria

[4] Bayero Univ, Aminu Kano Teaching Hosp, Dept Community Med, PMB 3452, Kano, Nigeria

[5] Lagos Univ, Univ Lagos, Teaching Hosp, Dept Community Med & Primary Care,Coll Med, PMB 12003, Lagos, Nigeria

来源：

SCIENTIFIC REPORTS | 2018年 / 8卷

基金：

英国惠康基金;

关键词：

NONTYPABLE HAEMOPHILUS-INFLUENZAE; MONITOR POSTVACCINATION CHANGES; D CONJUGATE VACCINE; STREPTOCOCCUS-PNEUMONIAE; ANTIMICROBIAL SUSCEPTIBILITY; SEROTYPE DISTRIBUTION; PHID-CV; DISEASE; CHILDREN; IMMUNOGENICITY;

D O I：

10.1038/s41598-018-21837-5

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Changes in nasopharyngeal (NP) carriage of vaccine-type (VT) Streptococcus pneumoniae can be used to assess the effectiveness of a pneumococcal conjugate vaccine (PCV10). We conducted a baseline carriage survey in rural (Kumbotso, Kano) and urban (Pakoto, Ogun) Nigeria. In this cross-sectional study, we obtained data on demography, clinical history, risk factors, and took NP swabs for pneumococcal culture. We calculated crude and age-standardised carriage prevalence and used log-binomial regression to assess risk factors for carriage. Among children aged <5 years, 92% (95% CI: 88-95%) and 78% (73-82%), respectively, carried any pneumococcus and 48% and 50%, respectively, carried PCV10 serotypes. In Kumbotso, carriage prevalence was >40% across all ages. The age-standardized prevalence of pneumococcal carriage was 66% in Kumbotso and 40% in Pakoto. The most commonly identified serotypes were 19 F, 6 A and 23 F. Risk factors for carriage were young age, recent rhinorrhoea, cohabitation with >= 2 children aged <5 years, and sharing a bed with >= 2 persons. Pneumococcal carriage prevalence is high in this Nigerian population. Persisting prevalence of VT-carriage in older children and adults suggests that PCV10 introduction in children will not eliminate transmission of vaccine serotypes rapidly. High vaccine coverage will therefore be required to ensure full protection of children.

引用

页数：9

共 53 条

[1] The descriptive epidemiology of Streptococcus pneumoniae and Haemophilus influenzae nasopharyngeal carriage in children and adults in Kilifi district, Kenya [J].

Abdullahi, Osman ;

Ayiro, Joyce ;

Lewa, Pole ;

Slack, Mary ;

Scott, J. Anthony G. .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2008, 27 (01) :59-64

[2] Serotype and antimicrobial susceptibility patterns of isolates of Streptococcus pneumoniae causing invasive disease in The Gambia 1996-2003 [J].

Adegbola, Richard A. ;

Hill, Philip C. ;

Secka, Ousman ;

Ikumapayi, Usman N. ;

Lahai, George ;

Greenwood, Brian M. ;

Corrah, Tumani .

TROPICAL MEDICINE & INTERNATIONAL HEALTH, 2006, 11 (07) :1128-1135

[3]

Adetifa I. M. O., 2016, 10 INT S PNEUM PNEUM

[4] Pre-Vaccination Nasopharyngeal Pneumococcal Carriage in a Nigerian Population: Epidemiology and Population Biology [J].

Adetifa, Ifedayo M. O. ;

Antonio, Martin ;

Okoromah, Christy A. N. ;

Ebruke, Chinelo ;

Inem, Victor ;

Nsekpong, David ;

Bojang, Abdoulie ;

Adegbola, Richard A. .

PLOS ONE, 2012, 7 (01)

[5] Identifying transmission routes of Streptococcus pneumoniae and sources of acquisitions in high transmission communities [J].

Althouse, B. M. ;

Hammitt, L. L. ;

Grant, L. ;

Wagner, B. G. ;

Reid, R. ;

Larzelere-Hinton, F. ;

Weatherholtz, R. ;

Klugman, K. P. ;

Rodgers, G. L. ;

O'Brien, K. L. ;

Hu, H. .

EPIDEMIOLOGY AND INFECTION, 2017, 145 (13) :2750-2758

[6]

[Anonymous], WHO Vaccine Preventable Diseases Monitoring System: 2012 global summary

[7] Impact of the 13-valent pneumococcal conjugate vaccine (pcv13) on invasive pneumococcal disease and carriage in Alaska [J].

Bruce, Michael G. ;

Singleton, Rosalyn ;

Bulkow, Lisa ;

Rudolph, Karen ;

Zulz, Tammy ;

Gounder, Prabhu ;

Hurlburt, Debby ;

Bruden, Dana ;

Hennessy, Thomas .

VACCINE, 2015, 33 (38) :4813-4819

[8] Pharyngeal carriage of Neisseria species in the African meningitis belt [J].

Diallo, Kanny ;

Trotter, Caroline ;

Timbine, Youssouf ;

Tamboura, Boubou ;

Sow, Samba O. ;

Issaka, Bassira ;

Dano, Ibrahim D. ;

Collard, Jean-Marc ;

Dieng, Marietou ;

Diallo, Aldiouma ;

Mihret, Adane ;

Ali, Oumer A. ;

Aseffa, Abraham ;

Quaye, Stephen L. ;

Bugri, Akalifa ;

Osei, Isaac ;

Gamougam, Kadidja ;

Mbainadji, Lodoum ;

Daugla, Doumagoum M. ;

Gadzama, Galadima ;

Sambo, Zailani B. ;

Omotara, Babatunji A. ;

Bennett, Julia S. ;

Rebbetts, Lisa S. ;

Watkins, Eleanor R. ;

Nascimento, Maria ;

Woukeu, Arouna ;

Manigart, Olivier ;

Borrow, Ray ;

Stuart, James M. ;

Greenwood, Brian M. ;

Maiden, Martin C. J. .

JOURNAL OF INFECTION, 2016, 72 (06) :667-677

[9] Invasive Pneumococcal Disease in Children Aged <5 Years Admitted to 3 Urban Hospitals in Ibadan, Nigeria [J].

Falade, A. G. ;

Lagunju, I. A. ;

Bakare, R. A. ;

Odekanmi, A. A. ;

Adegbola, R. A. .

CLINICAL INFECTIOUS DISEASES, 2009, 48 :S190-S196

[10] Serotype-Specific Changes in Invasive Pneumococcal Disease after Pneumococcal Conjugate Vaccine Introduction: A Pooled Analysis of Multiple Surveillance Sites [J].

Feikin, Daniel R. ;

Kagucia, Eunice W. ;

Loo, Jennifer D. ;

Link-Gelles, Ruth ;

Puhan, Milo A. ;

Cherian, Thomas ;

Levine, Orin S. ;

Whitney, Cynthia G. ;

O'Brien, Katherine L. ;

Moore, Matthew R. .

PLOS MEDICINE, 2013, 10 (09)

← 1 2 3 4 5 6 →