Mesenchymal Stem/Stromal Cells: A New "Cells as Drugs" Paradigm. Efficacy and Critical Aspects in Cell Therapy

被引：129
作者：
de Girolamo, Laura [1 ]
Lucarelli, Enrico [2 ]
Alessandri, Giulio [3 ]
Avanzini, Maria Antonietta [4 ]
Bernardo, Maria Ester [5 ]
Biagi, Ettore [6 ]
Brini, Anna Teresa [7 ]
D'Amico, Giovanna [8 ]
Fagioli, Franca [9 ]
Ferrero, Ivana [10 ]
Locatelli, Franco [5 ,11 ]
Maccario, Rita [4 ]
Marazzi, Mario [12 ]
Parolini, Ornella [13 ]
Pessina, Augusto [14 ]
Torre, Maria Luisa [15 ]
机构：
[1] IRCCS Ist Ortoped Galeazzi, Lab Biotecnol Applicate Ortopedia, Milan, Italy
[2] IRCCS Ist Ortoped Rizzoli, Lab Patol Ortoped & Rigeneraz Tissutale Osteoarti, Bologna, Italy
[3] Fdn IRCCS Ist Neurol Carlo Besta, Dipartimento Malattie Cerebrovasc, Milan, Italy
[4] Fdn IRCCS Policlin S Matteo, Lab Immunol & Trapianti, Pavia, Italy
[5] Ist Ricovero & Cura Carattere Sci Bambino Gesu, Dipartimento Oncoematol Pediat, Rome, Italy
[6] Univ Milano Bicocca, Osped San Gerardo, Dipartimento Pediat, Lab Terapia Cellulare Stefano Verri, Monza, Italy
[7] Univ Milan, IRCCS Ist Ortoped Galeazzi, Dipartimento Sci Biomed Chirurg & Odont, Lab Farmacol Cellule Staminali & Med Rigenerat, I-20133 Milan, Italy
[8] Univ Milano Bicocca, Pediat Clin, Ctr Ric M Tettamanti, Monza, Italy
[9] Osped Infantile Regina Margherita, Div Oncoematol Pediat, Turin, Italy
[10] Univ Turin, Azienda Osped OIRM S Anna, Dipartimento Sci Pediat & Adolescenza, Lab Ctr Trapianti Cellule Staminali & Terapia Cel, Turin, Italy
[11] Univ Pavia, Dipartimento Sci Clin Chirurg Diagnost & Pediat, I-27100 Pavia, Italy
[12] Azienda Osped Osped Niguarda Ca Granda, Milan, Italy
[13] Fdn Poliambulanza Ist Osped, Ctr Ric E Menni, Brescia, Italy
[14] Univ Milan, Lab Colture Cellulari, Dipartimento Sci Biomed Chirurg & Odont, I-20133 Milan, Italy
[15] Univ Pavia, Dipartimento Sci Farmaco, I-27100 Pavia, Italy
来源：
CURRENT PHARMACEUTICAL DESIGN | 2013年 / 19卷 / 13期
关键词：
Mesenchymal stem/stromal cells; cell therapy; graft versus host disease; immunomodulatory properties; regenerative medicine; advanced therapy medicinal product; transplantation; MSCs sources; HUMAN BONE-MARROW; UMBILICAL-CORD BLOOD; VERSUS-HOST-DISEASE; SPONTANEOUS MALIGNANT-TRANSFORMATION; AMYOTROPHIC-LATERAL-SCLEROSIS; ARTICULAR-CARTILAGE DEFECTS; STROMAL-VASCULAR FRACTION; HUMAN ADIPOSE-TISSUE; HUMAN STEM-CELLS; EX-VIVO;
D O I：
10.2174/1381612811319130015
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Mesenchymal stem cells (MSCs) were first isolated more than 50 years ago from the bone marrow. Currently MSCs may also be isolated from several alternative sources and they have been used in more than a hundred clinical trials worldwide to treat a wide variety of diseases. The MSCs mechanism of action is undefined and currently under investigation. For in vivo purposes MSCs must be produced in compliance with good manufacturing practices and this has stimulated research on MSCs characterization and safety. The objective of this review is to describe recent developments regarding MSCs properties, physiological effects, delivery, clinical applications and possible side effects.
引用
收藏
页码：2459 / 2473
页数：15
相关论文
共 221 条
  • [1] Enhanced Chondrocyte Proliferation and Mesenchymal Stromal Cells Chondrogenesis in Coculture Pellets Mediate Improved Cartilage Formation
    Acharya, Chitrangada
    Adesida, Adetola
    Zajac, Paul
    Mumme, Marcus
    Riesle, Jens
    Martin, Ivan
    Barbero, Andrea
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2012, 227 (01) : 88 - 97
  • [2] Cell-Cycle Phases and Genetic Profile of Bone Marrow-Derived Mesenchymal Stromal Cells Expanded In Vitro From Healthy Donors
    Achille, Valentina
    Mantelli, Melissa
    Arrigo, Giulia
    Novara, Francesca
    Avanzini, Maria Antonietta
    Bernardo, Maria Ester
    Zuffardi, Orsetta
    Barosi, Giovanni
    Zecca, Marco
    Maccario, Rita
    [J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 2011, 112 (07) : 1817 - 1821
  • [3] Al Battah F, 2011, THESCIENTIFICWORLDJO, V11, P1568, DOI [10.1100/tsw.2011.146, 10.1100/tsw.2011.146.]
  • [4] Transdifferentiation Potentiality of Human Wharton's Jelly Stem Cells Towards Vascular Endothelial Cells
    Alaminos, Miguel
    Perez-Koehler, Barbara
    Garzon, Ingrid
    Garcia-Honduvilla, Natalio
    Romer, Beatriz
    Campos, Antonio
    Bujan, Julia
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2010, 223 (03) : 640 - 647
  • [5] Cotransplantation of human stromal cell progenitors into preimmune fetal sheep results in early appearance of human donor cells in circulation and boosts cell levels in bone marrow at later time points after transplantation
    Almeida-Porada, G
    Porada, CD
    Tran, N
    Zanjani, ED
    [J]. BLOOD, 2000, 95 (11) : 3620 - 3627
  • [6] Aging alters tissue resident mesenchymal stem cell properties
    Alt, Eckhard U.
    Senst, Christiane
    Murthy, Subramanyam N.
    Slakey, Douglas P.
    Dupin, Charles L.
    Chaffin, Abigail E.
    Kadowitz, Philip J.
    Izadpanah, Reza
    [J]. STEM CELL RESEARCH, 2012, 8 (02) : 215 - 225
  • [7] [Anonymous], ANN PLAST SURG
  • [8] [Anonymous], MESENCHYMAL STROMAL
  • [9] [Anonymous], J TISSUE ENG REGEN M
  • [10] [Anonymous], BONE MARROW TRANSPLA
12345678910