Mesenchymal Stem/Stromal Cells: A New "Cells as Drugs" Paradigm. Efficacy and Critical Aspects in Cell Therapy

被引：130

作者：

de Girolamo, Laura ^{[1
]}

Lucarelli, Enrico ^{[2
]}

Alessandri, Giulio ^{[3
]}

Avanzini, Maria Antonietta ^{[4
]}

Bernardo, Maria Ester ^{[5
]}

Biagi, Ettore ^{[6
]}

Brini, Anna Teresa ^{[7
]}

D'Amico, Giovanna ^{[8
]}

Fagioli, Franca ^{[9
]}

Ferrero, Ivana ^{[10
]}

Locatelli, Franco ^{[5
,11
]}

Maccario, Rita ^{[4
]}

Marazzi, Mario ^{[12
]}

Parolini, Ornella ^{[13
]}

Pessina, Augusto ^{[14
]}

Torre, Maria Luisa ^{[15
]}

机构：

[1] IRCCS Ist Ortoped Galeazzi, Lab Biotecnol Applicate Ortopedia, Milan, Italy

[2] IRCCS Ist Ortoped Rizzoli, Lab Patol Ortoped & Rigeneraz Tissutale Osteoarti, Bologna, Italy

[3] Fdn IRCCS Ist Neurol Carlo Besta, Dipartimento Malattie Cerebrovasc, Milan, Italy

[4] Fdn IRCCS Policlin S Matteo, Lab Immunol & Trapianti, Pavia, Italy

[5] Ist Ricovero & Cura Carattere Sci Bambino Gesu, Dipartimento Oncoematol Pediat, Rome, Italy

[6] Univ Milano Bicocca, Osped San Gerardo, Dipartimento Pediat, Lab Terapia Cellulare Stefano Verri, Monza, Italy

[7] Univ Milan, IRCCS Ist Ortoped Galeazzi, Dipartimento Sci Biomed Chirurg & Odont, Lab Farmacol Cellule Staminali & Med Rigenerat, I-20133 Milan, Italy

[8] Univ Milano Bicocca, Pediat Clin, Ctr Ric M Tettamanti, Monza, Italy

[9] Osped Infantile Regina Margherita, Div Oncoematol Pediat, Turin, Italy

[10] Univ Turin, Azienda Osped OIRM S Anna, Dipartimento Sci Pediat & Adolescenza, Lab Ctr Trapianti Cellule Staminali & Terapia Cel, Turin, Italy

[11] Univ Pavia, Dipartimento Sci Clin Chirurg Diagnost & Pediat, I-27100 Pavia, Italy

[12] Azienda Osped Osped Niguarda Ca Granda, Milan, Italy

[13] Fdn Poliambulanza Ist Osped, Ctr Ric E Menni, Brescia, Italy

[14] Univ Milan, Lab Colture Cellulari, Dipartimento Sci Biomed Chirurg & Odont, I-20133 Milan, Italy

[15] Univ Pavia, Dipartimento Sci Farmaco, I-27100 Pavia, Italy

来源：

CURRENT PHARMACEUTICAL DESIGN | 2013年 / 19卷 / 13期

关键词：

Mesenchymal stem/stromal cells; cell therapy; graft versus host disease; immunomodulatory properties; regenerative medicine; advanced therapy medicinal product; transplantation; MSCs sources; HUMAN BONE-MARROW; UMBILICAL-CORD BLOOD; VERSUS-HOST-DISEASE; SPONTANEOUS MALIGNANT-TRANSFORMATION; AMYOTROPHIC-LATERAL-SCLEROSIS; ARTICULAR-CARTILAGE DEFECTS; STROMAL-VASCULAR FRACTION; HUMAN ADIPOSE-TISSUE; HUMAN STEM-CELLS; EX-VIVO;

D O I：

10.2174/1381612811319130015

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mesenchymal stem cells (MSCs) were first isolated more than 50 years ago from the bone marrow. Currently MSCs may also be isolated from several alternative sources and they have been used in more than a hundred clinical trials worldwide to treat a wide variety of diseases. The MSCs mechanism of action is undefined and currently under investigation. For in vivo purposes MSCs must be produced in compliance with good manufacturing practices and this has stimulated research on MSCs characterization and safety. The objective of this review is to describe recent developments regarding MSCs properties, physiological effects, delivery, clinical applications and possible side effects.

引用

页码：2459 / 2473

页数：15

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