ROS-dependent anticandidal activity of zinc oxide nanoparticles synthesized by using egg albumen as a biotemplate

被引：128
作者：
Shoeb, M. [1 ]
Singh, Braj R. [1 ]
Khan, Javed A. [1 ]
Khan, Wasi [1 ]
Singh, Brahma N. [2 ]
Singh, Harikesh B. [3 ]
Naqvi, Alim H. [1 ]
机构：
[1] Aligarh Muslim Univ, Ctr Excellence Mat Sci Nanomat, Dept Appl Phys, Zakir Hussain Coll Engn & Technol, Aligarh 202002, Uttar Pradesh, India
[2] Sowbhagya Biotech Private Ltd, Div Res & Dev, Hyderabad 500051, Andhra Pradesh, India
[3] Banaras Hindu Univ, Dept Mycol & Plant Pathol, Inst Agr Sci, Varanasi 221005, Uttar Pradesh, India
来源：
ADVANCES IN NATURAL SCIENCES-NANOSCIENCE AND NANOTECHNOLOGY | 2013年 / 4卷 / 03期
关键词：
nanoparticles; Candida albicans; anticandidal; ROS; APOPTOTIC CELL-DEATH; ZNO NANOPARTICLES; CANDIDA-ALBICANS; ANTIBACTERIAL ACTIVITY; OXIDATIVE STRESS; SILVER NANOPARTICLES; TOXICOLOGICAL IMPACT; ESCHERICHIA-COLI; PARTICLE-SIZE; BAND-GAP;
D O I：
10.1088/2043-6262/4/3/035015
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Zinc oxide nanoparticles (ZnO NPs) have attracted great attention because of their superior optical properties and wide application in biomedical science. However, little is known about the anticandidal activity of ZnO NPs against Candida albicans (C. albicans). This study was designed to develop the green approach to synthesize ZnO NPs using egg white (denoted as EtZnO NPs) and investigated its possible mechanism of antimicrobial activity against C. albicans 077. It was also notable that anticandidal activity of EtZnO NPs is correlated with reactive oxygen species (ROS) production in a dose dependent manner. Protection of histidine against ROS clearly suggests the implication of ROS in anticandidal activity of EtZnO NPs. This green approach based on egg white-mediated synthesis of ZnO NPs paves the way for developing cost effective, eco-friendly and promising antimicrobial nanomaterial for applications in medicine.
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页数：11
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