Delta Vs Gamma Auditory Steady State Synchrony in Schizophrenia

被引：27

作者：

Puvvada, Krishna C. ^{[1
]}

Summerfelt, Ann ^{[2
]}

Du, Xiaoming ^{[2
]}

Krishna, Nithin ^{[2
]}

Kochunov, Peter ^{[2
]}

Rowland, Laura M. ^{[2
]}

Simon, Jonathan Z. ^{[1
,3
,4
]}

Hong, L. Elliot ^{[2
]}

机构：

[1] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA

[2] Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Dept Psychiat, POB 21247, Baltimore, MD 21228 USA

[3] Univ Maryland, Dept Biol, College Pk, MD 20742 USA

[4] Univ Maryland, Inst Syst Res, College Pk, MD 20742 USA

来源：

SCHIZOPHRENIA BULLETIN | 2018年 / 44卷 / 02期

基金：

美国国家卫生研究院;

关键词：

auditory; hallucination; working memory; schizophrenia; auditory steady state; delta; gamma; ASSR; NMDA RECEPTOR; NEURAL OSCILLATIONS; DYNAMICS; EEG; ABNORMALITIES; EXCITABILITY; ENTRAINMENT; DYSFUNCTION; PARVALBUMIN; MECHANISMS;

D O I：

10.1093/schbul/sbx078

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background: Delta band (1-4 Hz) neuronal responses support the precision and stability of auditory processing, and a deficit in delta band synchrony may be relevant to auditory domain symptoms in schizophrenia patients. Methods: Delta band synchronization elicited by a 2.5 Hz auditory steady state response (ASSR) paradigm, along with those from theta (5 Hz), alpha (10 Hz), beta (20 Hz), gamma (40 Hz), and high gamma (80 Hz) frequency ASSR, were compared in 128 patients with schizophrenia, 108 healthy controls, and 55 first-degree relatives (FDR) of patients. Results: Delta band synchronization was significantly impaired in patients compared with controls (F = 18.3, P <.001). There was a significant 2.5 Hz by 40 Hz ASSR interaction (P = .023), arising from a greater reduction of 2.5 Hz ASSR than of 40 Hz ASSR, in patients compared with controls. Greater deficit in delta ASSR was associated with auditory perceptual abnormality (P = .007) and reduced verbal working memory (P <.001). Gamma frequency ASSR impairment was also significant but more modest (F = 8.7, P = .004), and this deficit was also present in FDR (P = .022). Conclusions: The ability to sustain delta band oscillation entrainment in the auditory pathway is significantly reduced in schizophrenia patients and appears to be clinically relevant.

引用

页码：378 / 387

页数：10