Purification of 2-[18F]fluoro-2-deoxy-D-glucose by on-chip solid-phase extraction

被引：14

作者：

Tarn, Mark D. ^{[1
]}

Pascali, Giancarlo ^{[2
]}

De Leonardis, Francesco ^{[1
]}

Watts, Paul ^{[1
]}

Salvadori, Piero A. ^{[2
]}

Pamme, Nicole ^{[1
]}

机构：

[1] Univ Hull, Dept Chem, Kingston Upon Hull HU6 7RX, N Humberside, England

[2] CNR, Inst Clin Physiol, Dept Radiopharmaceut Chem, I-56124 Pisa, Italy

来源：

JOURNAL OF CHROMATOGRAPHY A | 2013年 / 1280卷

关键词：

F-18]FDG; Microfluidic; Solid-phase extraction; Positron emission tomography; Radiotracer purification; POSITRON-EMISSION-TOMOGRAPHY; DRIVEN MICRO-REACTOR; MICROFLUIDIC DEVICES; PET; F-18; RADIOSYNTHESES; MICROREACTORS; SYSTEMS;

D O I：

10.1016/j.chroma.2013.01.032

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Microfluidic devices have shown great potential for the production of positron emission tomography (PET) radiotracers, but most devices have focused only on the synthesis step of the procedure, typically neglecting the other important steps such as [F-18]fluoride pre-concentration and radiotracer purification that could equally benefit from miniaturisation. Here, we demonstrate the development of microfluidic modules for the purification of PET radiotracers, particularly 2-[F-18]fluoro-2-deoxy-D-glucose ([F-18]FDG), via the use of on-chip solid-phase extraction (SPE). In these initial tests, the SPE modules were able to yield [F-18]FDG with up to 90% radiochemical purity, and methods are proposed for further increasing this value. (c) 2013 Elsevier B.V. All rights reserved.

引用

页码：117 / 121

页数：5

共 44 条

[1]

Arima V., UNPUB

[2] Positron emission tomography (PET) and microfluidic devices: A breakthrough on the microscale? [J].

Audrain, Helen .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (11) :1772-1775

[3] Synthesis of hypoxia imaging agent 1-(5-deoxy-5-fluoro-α-D-arabinofuranosyl)-2-nitroimidazole using microfluidic technology [J].

Bouvet, Vincent R. ;

Wuest, Melinda ;

Wiebe, Leonard I. ;

Wuest, Frank .

NUCLEAR MEDICINE AND BIOLOGY, 2011, 38 (02) :235-245

[4] Rapid and Efficient Radiosyntheses of meta-Substituted [18F]Fluoroarenes from [18F]Fluoride Ion and Diaryliodonium Tosylates within a Microreactor [J].

Chun, Joong-Hyun ;

Lu, Shuiyu ;

Pike, Victor W. .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2011, 2011 (23) :4439-4447

[5] Fast and High-Yield Microreactor Syntheses of ortho-Substituted [18F]Fluoroarenes from Reactions of [18F]Fluoride Ion with Diaryliodonium Salts [J].

Chun, Joong-Hyun ;

Lu, Shuiyu ;

Lee, Yong-Sok ;

Pike, Victor W. .

JOURNAL OF ORGANIC CHEMISTRY, 2010, 75 (10) :3332-3338

[6] Nitrogen supported solvent evaporation using continuous-flow microfluidics [J].

Cvetkovic, Benjamin Z. ;

Lade, Oliver ;

Marra, Lucia ;

Arima, Valentina ;

Rinaldi, Ross ;

Dittrich, Petra S. .

RSC ADVANCES, 2012, 2 (29) :11117-11122

[7] On-chip pre-concentration and complexation of [18F]fluoride ions via regenerable anion exchange particles for radiochemical synthesis of Positron Emission Tomography tracers [J].

De Leonardis, Francesco ;

Pascali, Giancarlo ;

Salvadori, Piero A. ;

Watts, Paul ;

Pamme, Nicole .

JOURNAL OF CHROMATOGRAPHY A, 2011, 1218 (29) :4714-4719

[8]

Ekström S, 2002, PROTEOMICS, V2, P413, DOI 10.1002/1615-9861(200204)2:4<413::AID-PROT413>3.0.CO

[9]

2-1

[10] Flow optimization study of a batch microfluidics PET tracer synthesizing device [J].

Elizarov, Arkadij M. ;

Meinhart, Carl ;

Miraghaie, Reza ;

van Dam, R. Michael ;

Huang, Jiang ;

Daridon, Antoine ;

Heath, James R. ;

Kolb, Hartmuth C. .

BIOMEDICAL MICRODEVICES, 2011, 13 (01) :231-242

← 1 2 3 4 5 →