Phase II trial of the pan-deacetylase inhibitor panobinostat as a single agent in advanced relapsed/refractory multiple myeloma

被引:109
作者
Wolf, Jeffrey L. [2 ]
Siegel, David [3 ]
Goldschmidt, Hartmut [4 ]
Hazell, Katharine [5 ]
Bourquelot, Priscille M. [5 ]
Bengoudifa, Bourras R. [5 ]
Matous, Jeffrey [6 ]
Vij, Ravi [7 ]
de Magalhaes-Silverman, Margarida [8 ]
Abonour, Rafat [9 ]
Anderson, Kenneth C. [10 ]
Lonial, Sagar [1 ]
机构
[1] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA
[2] Univ Calif San Francisco, San Francisco, CA 94143 USA
[3] Hackensack Univ, Med Ctr, Hackensack, NJ USA
[4] Heidelberg Univ, Heidelberg, Germany
[5] Novartis Pharma AG, Basel, Switzerland
[6] Colorado Blood Canc Inst, Denver, CO USA
[7] Washington Univ, St Louis, MO USA
[8] Univ Iowa, Iowa City, IA USA
[9] Indiana Univ, Ctr Canc, Indianapolis, IN 46204 USA
[10] Dana Farber Canc Inst, Boston, MA 02115 USA
关键词
BORTEZOMIB; LBH589; PROTEASOME; SURVIVAL;
D O I
10.3109/10428194.2012.661175
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:1820 / 1823
页数:4
相关论文
共 15 条
[1]   Development of the pan-DAC inhibitor panobinostat (LBH589): Successes and challenges [J].
Atadja, Peter .
CANCER LETTERS, 2009, 280 (02) :233-241
[2]   Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90 - A novel basis for antileukemia activity of histone deacetylase inhibitors [J].
Bali, P ;
Pranpat, M ;
Bradner, J ;
Balasis, M ;
Fiskus, W ;
Guo, F ;
Rocha, K ;
Kumaraswamy, S ;
Boyapalle, S ;
Atadja, P ;
Seto, E ;
Bhalla, K .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (29) :26729-26734
[3]   Aggresome induction by proteasome inhibitor bortezomib and α-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells [J].
Catley, Laurence ;
Weisberg, Ellen ;
Kiziltepe, Tanyel ;
Tai, Yu-Tzu ;
Hideshima, Teru ;
Neri, Paola ;
Tassone, Pierfrancesco ;
Atadja, Peter ;
Chauhan, Dharminder ;
Munshi, Nikhil C. ;
Anderson, Kenneth C. .
BLOOD, 2006, 108 (10) :3441-3449
[4]   International uniform response criteria for multiple myeloma [J].
Durie, B. G. M. ;
Harousseau, J-L ;
Miguel, J. S. ;
Blade, J. ;
Barlogie, B. ;
Anderson, K. ;
Gertz, M. ;
Dimopoulos, M. ;
Westin, J. ;
Sonneveld, P. ;
Ludwig, H. ;
Gahrton, G. ;
Beksac, M. ;
Crowley, J. ;
Belch, A. ;
Boccadaro, M. ;
Turesson, I. ;
Joshua, D. ;
Vesole, D. ;
Kyle, R. ;
Alexanian, R. ;
Tricot, G. ;
Attal, M. ;
Merlini, G. ;
Powles, R. ;
Richardson, P. ;
Shimizu, K. ;
Tosi, P. ;
Morgan, G. ;
Rajkumar, S. V. .
LEUKEMIA, 2006, 20 (09) :1467-1473
[5]   Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma [J].
Ellis, Leigh ;
Pan, Yan ;
Smyth, Gordon K. ;
George, Daniel J. ;
McCormack, Chris ;
Williams-Truax, Roxanne ;
Mita, Monica ;
Beck, Joachim ;
Burris, Howard ;
Ryan, Gail ;
Atadja, Peter ;
Butterfoss, Dale ;
Dugan, Margaret ;
Culver, Kenneth ;
Johnstone, Ricky W. ;
Prince, H. Miles .
CLINICAL CANCER RESEARCH, 2008, 14 (14) :4500-4510
[6]   Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma [J].
Hideshima, T ;
Bradner, JE ;
Wong, J ;
Chauhan, D ;
Richardson, P ;
Schreiber, SL ;
Anderson, KC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (24) :8567-8572
[7]   Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: A multicenter international myeloma working group study [J].
Kumar, S. K. ;
Lee, J. H. ;
Lahuerta, J. J. ;
Morgan, G. ;
Richardson, P. G. ;
Crowley, J. ;
Haessler, J. ;
Feather, J. ;
Hoering, A. ;
Moreau, P. ;
LeLeu, X. ;
Hulin, C. ;
Klein, S. K. ;
Sonneveld, P. ;
Siegel, D. ;
Blade, J. ;
Goldschmidt, H. ;
Jagannath, S. ;
Miguel, J. S. ;
Orlowski, R. ;
Palumbo, A. ;
Sezer, O. ;
Rajkumar, S. V. ;
Durie, B. G. M. .
LEUKEMIA, 2012, 26 (01) :149-157
[8]   Improved survival in multiple myeloma and the impact of novel therapies [J].
Kumar, Shaji K. ;
Rajkumar, S. Vincent ;
Dispenzieri, Angela ;
Lacy, Martha Q. ;
Hayman, Suzanne R. ;
Buadi, Francis K. ;
Zeldenrust, Steven R. ;
Dingli, David ;
Russell, Stephen J. ;
Lust, John A. ;
Greipp, Philip R. ;
Kyle, Robert A. ;
Gertz, Morie A. .
BLOOD, 2008, 111 (05) :2516-2520
[9]  
Kyle RA, 2003, BRIT J HAEMATOL, V121, P749
[10]   Phase 2 Trial of the Histone Deacetylase Inhibitor Romidepsin for the Treatment of Refractory Multiple Myeloma [J].
Niesvizky, Ruben ;
Ely, Scott ;
Mark, Tomer ;
Aggarwal, Sangeeta ;
Gabrilove, Janice L. ;
Wright, John J. ;
Chen-Kiang, Selina ;
Sparano, Joseph A. .
CANCER, 2011, 117 (02) :336-342