Protein microparticles with controlled stability prepared via layer-by-layer adsorption of biopolyelectrolytes

被引：19

作者：

Balabushevich, N. G. ^{[1
]}

Izumrudov, V. A. ^{[1
]}

Larionova, N. I. ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Fac Chem, Moscow 119991, Russia

来源：

POLYMER SCIENCE SERIES A | 2012年 / 54卷 / 07期

基金：

俄罗斯基础研究基金会;

关键词：

NONSTOICHIOMETRIC POLYELECTROLYTE COMPLEXES; POLYMERIC MULTILAYER CAPSULES; MICROSIZED CAPSULES; ALPHA-CHYMOTRYPSIN; CONTROLLED-RELEASE; MODIFIED CHITOSAN; ENZYME; MICROCAPSULES; ENCAPSULATION; INSULIN;

D O I：

10.1134/S0965545X12040098

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

This review covers the experimental data on the preparation and characterization of protein microparticles with controlled stability that are formed by layer-by-layer adsorption of oppositely charged macromolecules. Variants of using proteins as adsorbed polyelectrolyes, methods of incorporating proteins into matrixes (aggregates and microspheres) for further deposition of biopolyelectrolytes, and immobilization of proteins in preformed multilayered polyelectrolyte particles due to a change in the permeability of their shells are considered. Special attention is given to biocompatible and biodegradable microparticles characterized by depot functions, that is, the ability to reliably protect biologically active compounds from aggregative media of the body and to quantitatively release protein preparations (hormones, enzymes, and peptides) into solution when a certain acidity of solution is attained. This feature is especially important for designing peroral means of protein delivery.

引用

页码：540 / 551

页数：12

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