Breath-based diagnosis of fungal infections

被引：16

作者：

Acharige, Mahesh J. Thalavitiya ^{[1
,2
]}

Koshy, Seena ^{[1
,2
]}

Ismail, Nour ^{[1
,2
]}

Aloum, Obadah ^{[1
,2
]}

Jazaerly, Majd ^{[1
,2
]}

Astudillo, Carmen Leon ^{[2
,3
]}

Koo, Sophia ^{[1
,2
,4
]}

机构：

[1] Brigham & Womens Hosp, Div Infect Dis, 181 Longwood Ave,MCP642, Boston, MA 02115 USA

[2] Harvard Med Sch, 25 Shattuck St, Boston, MA 02115 USA

[3] Boston Childrens Hosp, Div Resp Dis, 300 Longwood Ave, Boston, MA 02115 USA

[4] Dana Farber Canc Inst, 450 Brookline Ave, Boston, MA 02215 USA

来源：

JOURNAL OF BREATH RESEARCH | 2018年 / 12卷 / 02期

关键词：

volatile organic compounds; fungal infection; diagnostics; GC-MS; GC-DMS; DIFFERENTIAL MOBILITY SPECTROMETRY; HEADSPACE SORPTIVE EXTRACTION; ASPERGILLUS-FUMIGATUS; INVASIVE ASPERGILLOSIS; ELECTRONIC NOSES; DISEASE; FINGERPRINTS; VOLATOME; EFFICACY;

D O I：

10.1088/1752-7163/aa98a1

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Invasive aspergillosis and other invasive fungal infections are associated with significant morbidity and mortality in immunocompromised patients, in large part due to limitations of existing diagnostic methods for these infections. Detection of species-specific volatile sesquiterpene metabolites of fungal origin in the breath of patients with invasive fungal infections allows the diagnosis and monitoring of these infections in vivo, non-invasively and more rapidly than possible with current diagnostic methods. While detection of exogenous microbial volatile metabolites in the breath has opened up a new and exciting dimension of diagnostic research and development in infectious diseases, we discuss the daunting challenges to volatile diagnostic biomarker discovery and clinical development.

引用

页数：6

共 31 条

[21]

Koshy S, 2017, IDWEEK 2017

[22] The Fumagillin Biosynthetic Gene Cluster in Aspergillus fumigatus Encodes a Cryptic Terpene Cyclase Involved in the Formation of β-trans-Bergamotene [J].

Lin, Hsiao-Ching ;

Chooi, Yit-Heng ;

Dhingra, Sourabh ;

Xu, Wei ;

Calvo, Ana M. ;

Tang, Yi .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (12) :4616-4619

[23] Use of circulating galactomannan screening for early diagnosis of invasive aspergillosis in allogeneic stem cell transplant recipients [J].

Maertens, J ;

Van Eldere, J ;

Verhaegen, J ;

Verbeken, E ;

Verschakelen, J ;

Boogaerts, M .

JOURNAL OF INFECTIOUS DISEASES, 2002, 186 (09) :1297-1306

[24] Analysis of Volatile Fingerprints for Monitoring Anti-Fungal Efficacy Against the Primary and Opportunistic Pathogen Aspergillus fumigatus [J].

Pont, Neus Planas ;

Kendall, Catherine A. ;

Magan, Naresh .

MYCOPATHOLOGIA, 2012, 173 (2-3) :93-101

[25] Critical issues for breath analysis [J].

Risby, Terence H. .

JOURNAL OF BREATH RESEARCH, 2008, 2 (03)

[26] Clinical Application of Volatile Organic Compound Analysis for Detecting Infectious Diseases [J].

Sethi, Shneh ;

Nanda, Ranjan ;

Chakraborty, Trinad .

CLINICAL MICROBIOLOGY REVIEWS, 2013, 26 (03) :462-475

[27] Mass spectrometry for real-time quantitative breath analysis [J].

Smith, David ;

Spanel, Patrik ;

Herbig, Jens ;

Beauchamp, Jonathan .

JOURNAL OF BREATH RESEARCH, 2014, 8 (02)

[28] Electronic noses and disease diagnostics [J].

Turner, APF ;

Magan, N .

NATURE REVIEWS MICROBIOLOGY, 2004, 2 (02) :161-166

[29] Breath Analysis Using Laser Spectroscopic Techniques: Breath Biomarkers, Spectral Fingerprints, and Detection Limits [J].

Wang, Chuji ;

Sahay, Peeyush .

SENSORS, 2009, 9 (10) :8230-8262

[30] Headspace sorptive extraction and GC-TOFMS for the identification of volatile fungal metabolites [J].

Wihlborg, Rachel ;

Pippitt, David ;

Marsili, Ray .

JOURNAL OF MICROBIOLOGICAL METHODS, 2008, 75 (02) :244-250

← 1 2 3 4 →