Breath-based diagnosis of fungal infections

被引：16

作者：

Acharige, Mahesh J. Thalavitiya ^{[1
,2
]}

Koshy, Seena ^{[1
,2
]}

Ismail, Nour ^{[1
,2
]}

Aloum, Obadah ^{[1
,2
]}

Jazaerly, Majd ^{[1
,2
]}

Astudillo, Carmen Leon ^{[2
,3
]}

Koo, Sophia ^{[1
,2
,4
]}

机构：

[1] Brigham & Womens Hosp, Div Infect Dis, 181 Longwood Ave,MCP642, Boston, MA 02115 USA

[2] Harvard Med Sch, 25 Shattuck St, Boston, MA 02115 USA

[3] Boston Childrens Hosp, Div Resp Dis, 300 Longwood Ave, Boston, MA 02115 USA

[4] Dana Farber Canc Inst, 450 Brookline Ave, Boston, MA 02215 USA

来源：

JOURNAL OF BREATH RESEARCH | 2018年 / 12卷 / 02期

关键词：

volatile organic compounds; fungal infection; diagnostics; GC-MS; GC-DMS; DIFFERENTIAL MOBILITY SPECTROMETRY; HEADSPACE SORPTIVE EXTRACTION; ASPERGILLUS-FUMIGATUS; INVASIVE ASPERGILLOSIS; ELECTRONIC NOSES; DISEASE; FINGERPRINTS; VOLATOME; EFFICACY;

D O I：

10.1088/1752-7163/aa98a1

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Invasive aspergillosis and other invasive fungal infections are associated with significant morbidity and mortality in immunocompromised patients, in large part due to limitations of existing diagnostic methods for these infections. Detection of species-specific volatile sesquiterpene metabolites of fungal origin in the breath of patients with invasive fungal infections allows the diagnosis and monitoring of these infections in vivo, non-invasively and more rapidly than possible with current diagnostic methods. While detection of exogenous microbial volatile metabolites in the breath has opened up a new and exciting dimension of diagnostic research and development in infectious diseases, we discuss the daunting challenges to volatile diagnostic biomarker discovery and clinical development.

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页数：6

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