Adipose tissue-specific increase in angiotensinogen expression and secretion in the obese (fa/fa) Zucker rat

被引：71

作者：

Hainault, I ^{[1
]}

Nebout, G ^{[1
]}

Turban, S ^{[1
]}

Ardouin, B ^{[1
]}

Ferré, P ^{[1
]}

Quignard-Boulangé, A ^{[1
]}

机构：

[1] Univ Paris 06, Ctr Biomed Cordeliers, INSERM, U465, F-75270 Paris 06, France

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 2002年 / 282卷 / 01期

关键词：

adipocyte; leptin; liver; renin; obesity-induced hypertension;

D O I：

10.1152/ajpendo.2002.282.1.E59

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated angiotensinogen (AGT) expression in adipose tissue and liver of Zucker rats during the onset of obesity. The developmental pattern of AGT expression (protein and mRNA) in liver was similar in both genotypes. In inguinal adipose tissue, AGT cell content was similar in suckling and weaned pups in lean rats, whereas it continuously increased with age in obese rats. AGT amount in adipocytes was unaffected by the genotype until weaning. Thereafter, adipocytes from obese rats displayed a significant increase in AGT content that was strengthened with age. Compared with the cell content, the amount of secreted AGT over 24 h was higher, and a genotype effect was observed as early as 14 days of age. Using fat cell populations differing by size, we showed that this AGT oversecretion was not solely related to adipocyte hypertrophy. Our results demonstrate that the fa genotype exerts a control on the production of AGT in a tissue-specific manner, suggesting a local role of AGT in the overdevelopment of adipose tissue.

引用

页码：E59 / E66

页数：8

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