Fully functional NK cells after unrelated cord blood transplantation

被引：48

作者：

Beziat, V. ^{[1
,2
]}

Nguyen, S. ^{[3
]}

Lapusan, S.

Hervier, B. ^{[1
,2
]}

Dhedin, N. ^{[3
]}

Bories, D. ^{[5
]}

Uzunov, M. ^{[3
]}

Boudifa, A. ^{[6
]}

Trebeden-Negre, H. ^{[7
]}

Norol, F. ^{[7
]}

Marjanovic, Z. ^{[4
]}

Marie, J-P ^{[4
]}

Vernant, J-P ^{[3
]}

Debre, P. ^{[1
,2
,6
]}

Rio, B. ^{[4
]}

Vieillard, V. ^{[1
,2
]}

机构：

[1] Hop La Pitie Salpetriere, INSERM, U543, F-75013 Paris, France

[2] Univ Paris, UPMC, F-75252 Paris, France

[3] Hop La Pitie Salpetriere, Serv Hematol Clin, F-75013 Paris, France

[4] Hop Hotel Dieu, Dept Hematol & Oncol Med, Paris, France

[5] Hop Henri Mondor, Unite Hematol Mol, F-94010 Creteil, France

[6] Hop La Pitie Salpetriere, Lab Immunol Cellulaire & Tissulaire, F-75013 Paris, France

[7] Hop La Pitie Salpetriere, Lab Therapie Cellulaire, F-75013 Paris, France

来源：

LEUKEMIA | 2009年 / 23卷 / 04期

关键词：

NK cells; cord blood transplantation; GvL effect; cytotoxicity; NK-cell maturation; NATURAL-KILLER-CELLS; BONE-MARROW-TRANSPLANTATION; DENDRITIC CELLS; T-CELLS; HEMATOPOIETIC TRANSPLANTS; ACTIVATING RECEPTORS; INHIBITORY RECEPTORS; ACUTE-LEUKEMIA; MISSING SELF; RECONSTITUTION;

D O I：

10.1038/leu.2008.343

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Promising results of umbilical cord blood transplantation (UCBT) from unrelated donors have been reported in patients with hematologic disorders. These transplants, having potential to trigger beneficial donor-versus-recipient natural killer (NK) cell-mediated alloreaction, we have conducted the first extensive analysis of the phenotypic and functional properties of NK cells after UCBT. NK cells from 25 patients with high-risk hematologic malignancies were compared with cells derived from both healthy adult and CB cells. We found that following UCBT, NK cells display not only some phenotypic features associated with maturity but also unique characteristics that make them fully functional against leukemic blasts. We propose that this full functionality of alloreactive donor-derived NK may drive graft-versus-leukemia reactions after UCBT.

引用

页码：721 / 728

页数：8

共 49 条

[1] Ligation of CD8α on human natural killer cells prevents activation-induced apoptosis and enhances cytolytic activity [J].

Addison, EG ;

North, J ;

Bakhsh, I ;

Marden, C ;

Haq, S ;

Al-Sarraj, S ;

Malayeri, R ;

Wickremasinghe, RG ;

Davies, JK ;

Lowdell, MW .

IMMUNOLOGY, 2005, 116 (03) :354-361

[2] EFFECT OF HLA COMPATIBILITY ON ENGRAFTMENT OF BONE-MARROW TRANSPLANTS IN PATIENTS WITH LEUKEMIA OR LYMPHOMA [J].

ANASETTI, C ;

AMOS, D ;

BEATTY, PG ;

APPELBAUM, FR ;

BENSINGER, W ;

BUCKNER, CD ;

CLIFT, R ;

DONEY, K ;

MARTIN, PJ ;

MICKELSON, E ;

NISPEROS, B ;

OQUIGLEY, J ;

RAMBERG, R ;

SANDERS, JE ;

STEWART, P ;

STORB, R ;

SULLIVAN, KM ;

WITHERSPOON, RP ;

THOMAS, ED ;

HANSEN, JA .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (04) :197-204

[3] Modification of P-selectin glycoprotein ligand-1 with a natural killer cell-restricted sulfated lactosamine creates an alternate ligand for L-selectin [J].

André, P ;

Spertini, O ;

Guia, S ;

Rihet, P ;

Dignat-George, F ;

Brailly, H ;

Sampol, J ;

Anderson, PJ ;

Vivier, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (07) :3400-3405

[4] Full haplotype-mismatched hematopoietic stem-cell transplantation: A phase II study in patients with acute leukemia at high risk of relapse [J].

Aversa, F ;

Terenzi, A ;

Tabilio, A ;

Falzetti, F ;

Carotti, A ;

Ballanti, S ;

Felicini, R ;

Falcinelli, F ;

Velardi, A ;

Ruggeri, L ;

Aloisi, T ;

Saab, JP ;

Santucci, A ;

Perruccio, K ;

Martelli, MP ;

Mecucci, C ;

Reisner, Y ;

Martelli, MF .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (15) :3447-3454

[5] Outcomes of 122 diverse adult and pediatric cord blood transplant recipients from a large cord blood bank [J].

Ballen, Karen K. ;

Haley, N. Rebecca ;

Kurtzberg, Joanne ;

Lane, Thomas A. ;

Lindgren, Bruce R. ;

Miller, John P. ;

Newman, Bruce ;

McCullough, Jeff .

TRANSFUSION, 2006, 46 (12) :2063-2070

[6] Umbilical cord blood transplantation: current state of the art [J].

Barker, JN ;

Wagner, JE .

CURRENT OPINION IN ONCOLOGY, 2002, 14 (02) :160-164

[7] Haploidentical allogeneic hematopoietic cell transplantation in adults using CD3/CD19 depletion and reduced intensity conditioning:: An update [J].

Bethge, Wolfgang A. ;

Faul, Christoph ;

Bornhaeuster, Martin ;

Stuhler, Gernot ;

Beelen, Dietrich W. ;

Lang, Peter ;

Stelljes, Matthias ;

Vogel, Wichard ;

Haegele, Matthias ;

Handgretinger, Rupert ;

Kanz, Lothar .

BLOOD CELLS MOLECULES AND DISEASES, 2008, 40 (01) :13-19

[8] NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs [J].

Borg, C ;

Jalil, A ;

Laderach, D ;

Maruyama, K ;

Wakasugi, H ;

Charrier, S ;

Ryffel, B ;

Cambi, A ;

Figdor, C ;

Vainchenker, W ;

Galy, A ;

Caignard, A ;

Zitvogel, L .

BLOOD, 2004, 104 (10) :3267-3275

[9] KIR reconstitution is altered by T cells in the graft and correlates with clinical outcomes after unrelated donor transplantation [J].

Cooley, S ;

McCullar, V ;

Wangen, R ;

Bergemann, TL ;

Spellman, S ;

Weisdorf, DJ ;

Miller, JS .

BLOOD, 2005, 106 (13) :4370-4376

[10] The biology of human natural killer-cell subsets [J].

Cooper, MA ;

Fehniger, TA ;

Caligiuri, MA .

TRENDS IN IMMUNOLOGY, 2001, 22 (11) :633-640

← 1 2 3 4 5 →