New phloroglucinol derivatives from Indonesian Baeckea frutescens

被引：20

作者：

Ito, Takuya ^{[1
]}

Nisa, Khoirun ^{[1
,2
]}

Rakainsa, Senda Kartika ^{[1
]}

Lallo, Sbehan ^{[3
]}

Morita, Hiroyuki ^{[1
]}

机构：

[1] Toyama Univ, Inst Nat Med, Toyama 9300194, Japan

[2] LIPI, Indonesian Inst Sci, Res Unit Nat Prod Technol, Jl Jogja Wonosari Km 31-5 Playen, Gunungkidul, Yogyakarta, Indonesia

[3] Hasanuddin Univ, Fac Pharm, Makassar 90245, South Sulawesi, Indonesia

来源：

TETRAHEDRON | 2017年 / 73卷 / 08期

基金：

日本学术振兴会;

关键词：

Baeckea frutescens; Myrtaceae; Indonesia; Phloroglucinol derivatives; Antiproliferative activity; ACYLPHLOROGLUCINOL DERIVATIVES; MYRTACEAE; LEAVES;

D O I：

10.1016/j.tet.2017.01.016

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chemical investigation of the leaves of Baeckea frutescens (Myrtacea) led to the isolation and characterization of five new phloroglucinol derivatives, baeckenones G-K (1-5), together with two known compounds, ursolic acid (6) and humulene (7). The chemical structures were determined by extensive 1D- and 2D-NMR, and MS spectroscopic analyses. Baeckenones J (4) and K (5) exhibited antiproliferative activities against human lung A549 and pancreatic PSN-1 cancer cell lines, with IC50 values ranging from 11.8 to 19.2 mu M. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：1177 / 1181

页数：5

共 17 条

[1]

ABRAHAM WR, 1987, Z NATURFORSCH C, V42, P79

[2]

Ahmad N. S., 2012, J PLANT STUDIES, V1, P101

[3] Essential Oils from Neotropical Myrtaceae: Chemical Diversity and Biological Properties [J].