small ORFs: A new class of essential genes for development

被引：14

作者：

Albuquerque, Joao Paulo ^{[1
]}

Tobias-Santos, Vitoria ^{[1
]}

Rodrigues, Aline Caceres ^{[1
]}

Mury, Flavia Borges ^{[1
,2
]}

da Fonseca, Rodrigo Nunes ^{[1
,2
]}

机构：

[1] Univ Fed Rio de Janeiro, Lab Integrado Bioquim Hatisaburo Masuda, Nucleo Ecol & Desenvolvimento Socioambiental, BR-27965045 Macae, RJ, Brazil

[2] Univ Fed Rio de Janeiro, Entomol Mol, Inst Nacl Ciencia & Tecnol, Rio De Janeiro, RJ, Brazil

来源：

GENETICS AND MOLECULAR BIOLOGY | 2015年 / 38卷 / 03期

关键词：

Tribolium; mlpt; pri; tarsal-less; Drosophila; POLYCISTRONIC MESSENGER-RNA; OPEN READING FRAMES; SACCHAROMYCES-CEREVISIAE; TRANSCRIPTION FACTOR; DROSOPHILA; PEPTIDES; SHAVENBABY; MORPHOGENESIS; DISCOVERY; EVOLUTION;

D O I：

10.1590/S1415-475738320150009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genes that contain small open reading frames (smORFs) constitute a new group of eukaryotic genes and are expected to represent 5% of the Drosophila melanogaster transcribed genes. In this review we provide a historical perspective of their recent discovery, describe their general mechanism and discuss the importance of smORFs for future genomic and transcriptomic studies. Finally, we discuss the biological role of the most studied smORF so far, the Mlpt/Pri/Tal gene in arthropods. The pleiotropic action of Mlpt/Pri/Tal in D. melanogaster suggests a complex evolutionary scenario that can be used to understand the origins, evolution and integration of smORFs into complex gene regulatory networks.

引用

页码：278 / 283

页数：6

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