Palladium-Catalyzed Radical Cascade lododifluoromethylation/Cyclization of 1,6-Enynes with Ethyl Difluoroiodoacetate

被引：95

作者：

Wang, Yu-Qi ^{[1
]}

He, Yu-Tao ^{[1
]}

Zhang, Lu-Lu ^{[1
]}

Wu, Xin-Xing ^{[1
]}

Liu, Xue-Yuan ^{[1
]}

Liang, Yong-Min ^{[1
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 17期

基金：

美国国家科学基金会;

关键词：

COPPER-MEDIATED DIFLUOROMETHYLATION; PERFLUOROALKYL IODIDES; SODIUM DITHIONITE; CYCLIZATION; FLUORINE; ALKENES; ALKYNES; ENYNES; CARBOCYCLIZATION; REAGENT;

D O I：

10.1021/acs.orglett.5b02068

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and convenient Pd-catalyzed radical cascade iododifluoromethylation/cyclization of 1,6-enynes with ethyl difluoroiodoacetate is demonstrated. The proposed transformation presents high stereoselectivity under mild and facile reaction conditions, thereby allowing an efficient access to a variety of iodine-containing difluoromethylated pyrrolidines. A possible radical pathway for the transformation is proposed on the basis of the results of control experiments and relevant literature reviews.

引用

页码：4280 / 4283

页数：4

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