Synthesis of Enantiomerically Enriched Triarylmethanes by Enantiospecific Suzuki-Miyaura Cross-Coupling Reactions

被引：141

作者：

Matthew, Smitha C. ^{[1
]}

Glasspoole, Ben W. ^{[1
]}

Eisenberger, Patrick ^{[1
]}

Crudden, Cathleen M. ^{[1
,2
]}

机构：

[1] Queens Univ, Dept Chem, Kingston, ON K7L 3N6, Canada

[2] Nagoya Univ, Inst Transformat Biomol WPI ITbM, Chikusa Ku, Nagoya, Aichi 4648602, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 16期

基金：

加拿大创新基金会; 加拿大自然科学与工程研究理事会;

关键词：

BORONIC ESTERS; LITHIATION-BORYLATION; SECONDARY ALCOHOLS; RETENTION; INVERSION; CONVERSION; ARYLATION; BONDS; ACIDS;

D O I：

10.1021/ja412159g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The Suzuki-Miyaura cross-coupling of chiral, enantiomerically enriched dibenzylic boronic esters is described. The reaction proceeds with almost complete retention of stereochemistry, providing access to triaryl-methanes, compounds that have high biological activity and are difficult to prepare in enantiomerically pure form using other methods.

引用

页码：5828 / 5831

页数：4

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