Anti-PD1 Pembrolizumab Can Induce Exceptional Fulminant Type 1 Diabetes

被引:135
作者
Gaudy, Caroline [1 ,2 ,3 ]
Clevy, Celine [1 ,2 ]
Monestier, Sandrine [1 ,2 ]
Dubois, Noemie [4 ]
Preau, Yanis [4 ]
Mallet, Stephanie [1 ,2 ]
Richard, Marie-Aleth [1 ,2 ,3 ]
Grob, Jean-Jacques [1 ,2 ,3 ]
Valero, Rene [4 ,5 ,6 ]
Beliard, Sophie [4 ,5 ,6 ,7 ]
机构
[1] La Timone Hosp, AP HM, Dept Dermatol, Marseille, France
[2] La Timone Hosp, AP HM, Dept Oncol, Marseille, France
[3] INSERM, UMRS 911, F-13258 Marseille, France
[4] La Concept Hosp, AP HM, Dept Nutr Metab Dis & Endocrinol, Marseille, France
[5] Aix Marseille Univ, Fac Med, Marseille, France
[6] INSERM, UMR 1062, F-13258 Marseille, France
[7] INRA, UMR 1260, Marseille, France
关键词
D O I
10.2337/dc15-1331
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:E182 / E183
页数:2
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共 5 条
  • [1] Low programmed cell death-1 (PD-1) expression in peripheral CD4+ T cells in Japanese patients with autoimmune type 1 diabetes
    Fujisawa, R.
    Haseda, F.
    Tsutsumi, C.
    Hiromine, Y.
    Noso, S.
    Kawabata, Y.
    Mitsui, S.
    Terasaki, J.
    Ikegami, H.
    Imagawa, A.
    Hanafusa, T.
    [J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2015, 180 (03) : 452 - 457
  • [2] Precipitation of Autoimmune Diabetes With Anti-PD-1 Immunotherapy
    Hughes, Jing
    Vudattu, Nalini
    Sznol, Mario
    Gettinger, Scott
    Kluger, Harriet
    Lupsa, Beatrice
    Herold, Kevan C.
    [J]. DIABETES CARE, 2015, 38 (04) : e55 - e57
  • [3] Fulminant type 1 diabetes - an important subtype in East Asia
    Imagawa, Akihisa
    Hanafusa, Toshiaki
    [J]. DIABETES-METABOLISM RESEARCH AND REVIEWS, 2011, 27 (08) : 959 - 964
  • [4] Blockade of the Programmed Death-1 (PD1) Pathway Undermines Potent Genetic Protection from Type 1 Diabetes
    Kochupurakkal, Nora M.
    Kruger, Annie J.
    Tripathi, Sudipta
    Zhu, Bing
    Adams, La Tonya
    Rainbow, Daniel B.
    Rossini, Aldo
    Greiner, Dale L.
    Sayegh, Mohamed H.
    Wicker, Linda S.
    Guleria, Indira
    [J]. PLOS ONE, 2014, 9 (02):
  • [5] Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial
    Robert, Caroline
    Ribas, Antoni
    Wolchok, Jedd D.
    Hodi, F. Stephen
    Hamid, Omid
    Kefford, Richard
    Weber, Jeffrey S.
    Joshua, Anthony M.
    Hwu, Wen-Jen
    Gangadhar, Tara C.
    Patnaik, Amita
    Dronca, Roxana
    Zarour, Hassane
    Joseph, Richard W.
    Boasberg, Peter
    Chmielowski, Bartosz
    Mateus, Christine
    Postow, Michael A.
    Gergich, Kevin
    Elassaiss-Schaap, Jeroen
    Li, Xiaoyun Nicole
    Iannone, Robert
    Ebbinghaus, Scot W.
    Kang, S. Peter
    Daud, Adil
    [J]. LANCET, 2014, 384 (9948) : 1109 - 1117