Direct one-pot synthesis of zolimidine pharmaceutical drug and imidazo[1,2-a]pyridine derivatives via I2/CuO-promoted tandem strategy

被引：40

作者：

Cai, Qun ^{[1
]}

Liu, Mei-Cai ^{[1
]}

Mao, Bi-Ming ^{[1
]}

Xie, Xuan ^{[1
]}

Jia, Feng-Cheng ^{[1
]}

Zhu, Yan-Ping ^{[1
]}

Wu, An-Xin ^{[1
]}

机构：

[1] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2015年 / 26卷 / 07期

基金：

中国国家自然科学基金;

关键词：

2-Aminopyridines; Aromatic ketones; Imidazo[1,2-a]pyridines; Zolimidine; One-pot; BETA-KETO-ESTERS; EFFICIENT; AMINOPYRIDINES; IODINATION; INHIBITORS;

D O I：

10.1016/j.cclet.2014.12.016

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient one-pot synthetic protocol was developed for the synthesis of imidazo[1,2-a]pyridines from easily available starting materials: Aromatic ketones, alpha,beta-unsaturated ketones, beta-keto esters and 2-aminopyridines. The present reaction proceeded well in MeOH under the media of I-2/CuO. By using this method, the marketed drug zolimidine could be prepared easily with 95% yield. All these target products were characterized by NMR, HRMS and IR spectra. Furthermore, the target compound 3fa was determined by X-ray crystallographic analysis. (C) 2014 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：881 / 884

页数：4

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