Mitochondrial Dysfunction and Oxidative Damage in the Molecular Pathology of Parkinson's Disease

被引：8

作者：

Shadrina, M. I. ^{[1
]}

Slominsky, P. A. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Mol Genet, Moscow 123182, Russia

来源：

MOLECULAR BIOLOGY | 2008年 / 42卷 / 05期

关键词：

Parkinson's disease; dopaminergic neurons; mitochondrial dysfunction; oxidative damage;

D O I：

10.1134/S0026893308050099

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Parkinson's disease is a complex disorder that is characterized by progressive degeneration of nigrostriatal dopaminergic neurons. Its development is determined by the interaction between the genetic constitution of a body and environmental factors. Analysis of the genes associated with monogenic forms of Parkinson's disease implicated proteasomal degradation, differentiation of dopaminergic neurons, mitochondrial dysfunction, and oxidative damage in its pathogenesis. The review considers ample data that suggest a key role for mitochondrial dysfunction and oxidative stress.

引用

页码：720 / 728

页数：9

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