Distribution of Transglutaminase 6 in the Central Nervous System of Adult Mice

被引：19

作者：

Liu, Yu-Tao ^{[1
]}

Tang, Bei-Sha ^{[1
,2
,3
]}

Lan, Wei ^{[4
,5
]}

Song, Ning-Ning ^{[4
,5
]}

Huang, Ying ^{[4
,5
]}

Zhang, Lei ^{[4
,5
]}

Guan, Wen-Juan ^{[1
]}

Shi, Yu-Ting ^{[1
]}

Shen, Lu ^{[1
,2
,3
]}

Jiang, Hong ^{[1
,2
,3
]}

Guo, Ji-Feng ^{[1
,2
,3
]}

Xia, Kun ^{[2
]}

Ding, Yu-Qiang ^{[4
,5
]}

Wang, Jun-Ling ^{[1
,2
,3
]}

机构：

[1] Cent S Univ, Dept Neurol, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China

[2] State Key Lab Med Genet, Changsha 410008, Hunan, Peoples R China

[3] Cent S Univ, Neurodegenerat Disorders Res Ctr, Changsha 410008, Hunan, Peoples R China

[4] Tongji Univ, East Hosp, Sch Med, Key Lab Arrhythmias,Minist Educ China, Shanghai 200092, Peoples R China

[5] Tongji Univ, Sch Med, Dept Anat & Neurobiol, Shanghai 200092, Peoples R China

来源：

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY | 2013年 / 296卷 / 10期

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

spinocerebellar ataxia; transglutaminase; 6; immunohistochemistry; brain; distribution; SPINOCEREBELLAR ATAXIAS; SUBSTANTIA-NIGRA; CEREBELLUM; APOPTOSIS; DISEASE; GENE;

D O I：

10.1002/ar.22741

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Our previous study identified a new form of spinocerebellar ataxia (SCA), in which mutations in the gene coding for transglutaminase 6 (TG6) were suggested to be causative. However, the data concerning cellular distribution of TG6 in the brain is still fragmentary. Therefore, we now report a comprehensive immunohistochemical examination of the expression profile of TG6 in adult mouse brain. TG6 was abundantly expressed in the septal region, basal ganglia, hypothalamus and brainstem. Notably, numerous TG6-positive neurons were found in the key brain regions involved in regulating locomotion activity, including the globus pallidus, subthalamic nucleus, substantia nigra, cerebellum, some precerebellar nuclei, and spinal motor neurons. Double immunostaining showed that the vast majority of TG6-positive neurons in the reticular nigra were GABAergic and those in the compact nigra were not dopaminergic. In addition, double staining for TG6 with either anti-NeuN or glial fibrillary acidic protein (GFAP) antibodies demonstrated exclusive NeuN-TG6 co-localization. This study presents a comprehensive overview of TG6 expression in the mouse brain, and provides insight for investigating the role of TG6 in the development of SCA. Anat Rec, 296:1576-1587, 2013. (c) 2013 Wiley Periodicals, Inc.

引用

页码：1576 / 1587

页数：12

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