Early radiation exposures and BRCA1-associated breast cancer in young women from Poland

被引：27

作者：

Gronwald, Jacek ^{[2
]}

Pijpe, Anouk ^{[3
]}

Byrski, Tomasz ^{[2
]}

Huzarski, Tomasz ^{[2
]}

Stawicka, Malgorzata ^{[4
]}

Cybulski, Cezary ^{[2
]}

van Leeuwen, Flora ^{[3
]}

Lubinski, Jan ^{[2
]}

Narod, Steven A. ^{[1
]}

机构：

[1] Womens Coll Res Inst, Toronto, ON M5G 1N8, Canada

[2] Pomeranian Med Univ, Int Hereditary Canc Ctr, Dept Genet & Pathol, Szczecin, Poland

[3] Netherlands Canc Inst, Dept Epidemiol, Amsterdam, Netherlands

[4] Prophylact & Epidemiol Ctr, Poznan, Poland

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2008年 / 112卷 / 03期

关键词：

Breast cancer; BRCA1; gene; Carcinogenesis; Radiation;

D O I：

10.1007/s10549-008-9892-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To study whether or not there is an adverse effect of early chest X-rays on breast cancer risk in breast cancer susceptibility gene 1 (BRCA1) carriers, we compared the histories of chest X-ray exposures before age 30 in 138 BRCA1 carriers with breast cancer with 158 age-matched women with breast cancer, but without a BRCA1 mutation. All cases were drawn from a national breast cancer research registry. Affected carriers reported more frequent chest X-ray use before age 20 than affected non-carriers (0.6 vs. 0.3; P = 0.01). Affected carriers had, on average, 1.8 chest X-rays before age 30 compared to an average of 1.0 for affected non-carriers (P = 0.002). The odds ratio for ever having had a chest X-ray below age 30, given a BRCA1 mutation, was 1.8 [95% confidence interval (CI) = 1.2-2.9; P = 0.01]. These observations support the hypothesis that early radiation exposure may be a risk factor for breast cancer in BRCA1 carriers.

引用

页码：581 / 584

页数：4

共 13 条

[1] Effect of mammography on breast cancer risk in women with mutations in BRCA1 or BRCA2 [J].

Goldfrank, Deborah ;

Chuai, Shannon ;

Bernstein, Jonine L. ;

y Cajal, Teresa Ramon ;

Lee, Johanna B. ;

Alonso, M. Carmen ;

Diez, Orland ;

Baiget, Monserrat ;

Kauff, Noah D. ;

Offit, Kenneth ;

Robson, Mark .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2006, 15 (11) :2311-2313

[2] A high proportion of founder BRCA1 mutations in Polish breast cancer families [J].

Górski, B ;

Jakubowska, A ;

Huzarski, T ;

Byrski, T ;

Gronwald, J ;

Grzybowska, E ;

Mackiewicz, A ;

Stawicka, M ;

Bebenek, M ;

Sorokin, D ;

Fiszer-Maliszewska, L ;

Haus, O ;

Janiszewska, H ;

Niepsuj, S ;

Gózdz, S ;

Zaremba, L ;

Posmyk, M ;

Pluzanska, M ;

Kilar, E ;

Czudowska, D ;

Wasko, B ;

Miturski, R ;

Kowalczyk, JR ;

Urbanski, K ;

Szwiec, M ;

Koc, J ;

Debniak, B ;

Rozmiarek, A ;

Debniak, T ;

Cybulski, C ;

Kowalska, E ;

Toloczko-Grabarek, A ;

Zajaczek, S ;

Menkiszak, J ;

Medrek, K ;

Masojc, B ;

Mierzejewski, M ;

Narod, SA ;

Lubinski, J .

INTERNATIONAL JOURNAL OF CANCER, 2004, 110 (05) :683-686

[3] BREAST-CANCER IN WOMEN WITH SCOLIOSIS EXPOSED TO MULTIPLE DIAGNOSTIC X-RAYS [J].

HOFFMAN, DA ;

LONSTEIN, JE ;

MORIN, MM ;

VISSCHER, W ;

HARRIS, BSH ;

BOICE, JD .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1989, 81 (17) :1307-1312

[4] Incidence of female breast cancer among atomic bomb survivors, Hiroshima and Nagasaki, 1950-1990 [J].

Land, CE ;

Tokunaga, M ;

Koyama, K ;

Soda, M ;

Preston, DL ;

Nishimori, I ;

Tokuoka, S .

RADIATION RESEARCH, 2003, 160 (06) :707-717

[5] hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response [J].

Lee, JS ;

Collins, KM ;

Brown, AL ;

Lee, CH ;

Chung, JH .

NATURE, 2000, 404 (6774) :201-204

[6] BRCA1-positive breast cancers in young women from Poland [J].

Lubinski, J. ;

Gorski, B. ;

Huzarski, T. ;

Byrski, T. ;

Gronwald, J. ;

Serrano-Fernandez, P. ;

Domagala, W. ;

Chosia, M. ;

Ucinski, M. ;

Grzybowska, E. ;

Lange, D. ;

Maka, B. ;

Mackiewicz, A. ;

Karczewska, A. ;

Breborowicz, J. ;

Lamperska, K. ;

Stawicka, M. ;

Gozdecka-Grodecka, S. ;

Bebenek, M. ;

Sorokin, D. ;

Wojnar, A. ;

Haus, O. ;

Sir, J. ;

Mierzwa, T. ;

Niepsuj, S. ;

Gugala, K. ;

Gozdz, S. ;

Sygut, J. ;

Kozak-Klonowska, B. ;

Musiatowicz, B. ;

Posmyk, M. ;

Kordek, R. ;

Morawiec, M. ;

Zambrano, O. ;

Wasko, B. ;

Fudali, L. ;

Skret, J. ;

Surdyka, D. ;

Urbanski, K. ;

Mitus, J. ;

Rys, J. ;

Szwiec, M. ;

Rozmiarek, A. ;

Dziuba, I. ;

Wandzel, P. ;

Wisniowski, R. ;

Szczylik, C. ;

Kozak, A. ;

Kozlowski, W. ;

Narod, S. A. .

BREAST CANCER RESEARCH AND TREATMENT, 2006, 99 (01) :71-76

[7] Screening mammography and risk of breast cancer in BRCA1 and BRCA2 mutation carriers:: a case-control study [J].

Narod, Steven A. ;

Lubinski, Jan ;

Ghadirian, Parviz ;

T Lynch, Henry ;

Moller, Pal ;

Foulkes, William D. ;

Rosen, Barry ;

Kim-Sing, Charmaine ;

Isaacs, Claudine ;

Domcheck, Susan ;

Sun, Ping .

LANCET ONCOLOGY, 2006, 7 (05) :402-406

[8]

Preston DL, 2002, RADIAT RES, V158, P220, DOI 10.1667/0033-7587(2002)158[0220:REOBCR]2.0.CO

[9]

[10] Roles of radiation dose, chemotherapy, and hormonal factors in breast cancer following Hodgkin's disease [J].

van Leeuwen, FE ;

Klokman, WJ ;

Stovall, M ;

Dahler, EC ;

van't Veer, MB ;

Noordijk, EM ;

Crommelin, MA ;

Aleman, BMP ;

Broeks, A ;

Gospodarowicz, M ;

Travis, LB ;

Russell, NS .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2003, 95 (13) :971-980

← 1 2 →