Management of Severe Recurrent Focal Segmental Glomerulosclerosis Through Circulating Soluble Urokinase Receptor Modification

被引：21

作者：

Morath, Christian ^{[1
]}

Wei, Changli ^{[2
]}

Macher-Goeppinger, Stephan ^{[3
]}

Schwenger, Vedat ^{[1
]}

Zeier, Martin ^{[1
]}

Reiser, Jochen ^{[2
]}

机构：

[1] Heidelberg Univ, Dept Med, Div Nephrol, D-69120 Heidelberg, Germany

[2] Rush Univ, Med Ctr, Dept Med, Chicago, IL 60612 USA

[3] Heidelberg Univ, Dept Pathol, D-69120 Heidelberg, Germany

来源：

AMERICAN JOURNAL OF THERAPEUTICS | 2013年 / 20卷 / 02期

关键词：

apheresis; circulating factor; FSGS; transplantation;

D O I：

10.1097/MJT.0b013e3182811aca

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Circulating soluble urokinase receptor (suPAR) was recently identified as one of the causes responsible for native and recurrent focal segmental glomerulosclerosis (FSGS) through overactivation of podocyte beta(3) integrin. Here, we discuss the management of a patient with very high suPAR serum levels and FSGS recurrence. The suPAR reduction using plasmapheresis and immunoadsorption allowed for lowering of suPAR and reduced podocyte beta(3) integrin activation and proteinuria. The patient is successfully weaned to bimonthly suPAR removal treatments with improved renal parameters. In summary, we provide an approach for the successful management of severe recurrent FSGS using available therapies with biomarker guidance.

引用

页码：226 / 229

页数：4

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