Is it possible to eradicate long-term MRSA of a hemodialysis service? The MRSA are resistant microorganisms to a wide range of beta-lactam antibiotics, which produce infections in outpatients and hospitalized, associated with the character of nasopharyngeal carrier and increasing morbidity and mortality in critical areas of health-care, such as intensive care and hemodialysis. The objective is to assess long-term implementation of a treatment to eradicate the character of nasopharyngeal carrier of MRSA in hemodialysis unit patients of HGZ-No 1 of IMSS. 2006-2008. It is a descriptive study on age, sex and concomitant disease of patients with methicillin-resistant staphylococcus. Analytical on the eradication short and longterm nature of these microorganisms. In the long-term assessment of all patients admitted with MRSA, the bearing was eradicated in 100% ((16)), p <0.05. Of those that MRCNS were originally isolated ((57)), the long-term eradication was 85.96% ((49)) (p <0.001). In this study long-term bearering of MRSA was eradicated by applying a prophylactic rifampin and trimethoprim / sulfamethoxazole based treatment, on the CNS carriers of methicillin-resistant, the number of strains decreased on a high percentage, with statistically significant results for both.