Rac1 in the driver's seat for melanoma

被引:12
作者
Machesky, Laura M. [1 ]
Sansom, Owen J. [1 ]
机构
[1] Univ Glasgow, Beatson Inst Canc Res, Coll Med Vet & Life Sci, Glasgow G61 1BD, Lanark, Scotland
关键词
NF-KAPPA-B; ACTIVATION; METASTASIS; MUTATIONS; INVASION; ABILITY; GTPASES; CANCER; PAK1; GENE;
D O I
10.1111/pcmr.12004
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:762 / 764
页数:3
相关论文
共 27 条
[1]   Activation of Vav/Rho GTPase signaling by CXCL12 controls membrane-type matrix metalloproteinase-dependent melanoma cell invasion [J].
Bartolomé, RA ;
Molina-Ortiz, I ;
Samaniego, R ;
Sánchez-Mateos, P ;
Bustelo, XR ;
Teixidó, J .
CANCER RESEARCH, 2006, 66 (01) :248-258
[2]   Melanoma genome sequencing reveals frequent PREX2 mutations [J].
Berger, Michael F. ;
Hodis, Eran ;
Heffernan, Timothy P. ;
Deribe, Yonathan Lissanu ;
Lawrence, Michael S. ;
Protopopov, Alexei ;
Ivanova, Elena ;
Watson, Ian R. ;
Nickerson, Elizabeth ;
Ghosh, Papia ;
Zhang, Hailei ;
Zeid, Rhamy ;
Ren, Xiaojia ;
Cibulskis, Kristian ;
Sivachenko, Andrey Y. ;
Wagle, Nikhil ;
Sucker, Antje ;
Sougnez, Carrie ;
Onofrio, Robert ;
Ambrogio, Lauren ;
Auclair, Daniel ;
Fennell, Timothy ;
Carter, Scott L. ;
Drier, Yotam ;
Stojanov, Petar ;
Singer, Meredith A. ;
Voet, Douglas ;
Jing, Rui ;
Saksena, Gordon ;
Barretina, Jordi ;
Ramos, Alex H. ;
Pugh, Trevor J. ;
Stransky, Nicolas ;
Parkin, Melissa ;
Winckler, Wendy ;
Mahan, Scott ;
Ardlie, Kristin ;
Baldwin, Jennifer ;
Wargo, Jennifer ;
Schadendorf, Dirk ;
Meyerson, Matthew ;
Gabriel, Stacey B. ;
Golub, Todd R. ;
Wagner, Stephan N. ;
Lander, Eric S. ;
Getz, Gad ;
Chin, Lynda ;
Garraway, Levi A. .
NATURE, 2012, 485 (7399) :502-506
[3]   Molecular cytogenetics of cutaneous melanocytic lesions - diagnostic, prognostic and therapeutic aspects [J].
Blokx, Willeke Am M. ;
van Dijk, Marcory C. R. F. ;
Ruiter, Dirk J. .
HISTOPATHOLOGY, 2010, 56 (01) :121-132
[4]   Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway [J].
Brown, JL ;
Stowers, L ;
Baer, M ;
Trejo, J ;
Coughlin, S ;
Chant, J .
CURRENT BIOLOGY, 1996, 6 (05) :598-605
[5]   Mutations of the BRAF gene in human cancer [J].
Davies, H ;
Bignell, GR ;
Cox, C ;
Stephens, P ;
Edkins, S ;
Clegg, S ;
Teague, J ;
Woffendin, H ;
Garnett, MJ ;
Bottomley, W ;
Davis, N ;
Dicks, N ;
Ewing, R ;
Floyd, Y ;
Gray, K ;
Hall, S ;
Hawes, R ;
Hughes, J ;
Kosmidou, V ;
Menzies, A ;
Mould, C ;
Parker, A ;
Stevens, C ;
Watt, S ;
Hooper, S ;
Wilson, R ;
Jayatilake, H ;
Gusterson, BA ;
Cooper, C ;
Shipley, J ;
Hargrave, D ;
Pritchard-Jones, K ;
Maitland, N ;
Chenevix-Trench, G ;
Riggins, GJ ;
Bigner, DD ;
Palmieri, G ;
Cossu, A ;
Flanagan, A ;
Nicholson, A ;
Ho, JWC ;
Leung, SY ;
Yuen, ST ;
Weber, BL ;
Siegler, HF ;
Darrow, TL ;
Paterson, H ;
Marais, R ;
Marshall, CJ ;
Wooster, R .
NATURE, 2002, 417 (6892) :949-954
[6]   Stimulation of NFκB activity by multiple signaling pathways requires PAK1 [J].
Frost, JA ;
Swantek, JL ;
Stippec, S ;
Yin, MJ ;
Gaynor, R ;
Cobb, MH .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (26) :19693-19699
[7]   DOCK10-Mediated Cdc42 Activation Is Necessary for Amoeboid Invasion of Melanoma Cells [J].
Gadea, Gilles ;
Sanz-Moreno, Victoria ;
Self, Annette ;
Godi, Anna ;
Marshall, Christopher J. .
CURRENT BIOLOGY, 2008, 18 (19) :1456-1465
[8]  
Gysin Stephan, 2011, Genes Cancer, V2, P359, DOI 10.1177/1947601911412376
[9]   Mammalian Rho GTPases:: new insights into their functions from in vivo studies [J].
Heasman, Sarah J. ;
Ridley, Anne J. .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2008, 9 (09) :690-701
[10]   A Landscape of Driver Mutations in Melanoma [J].
Hodis, Eran ;
Watson, Ian R. ;
Kryukov, Gregory V. ;
Arold, Stefan T. ;
Imielinski, Marcin ;
Theurillat, Jean-Philippe ;
Nickerson, Elizabeth ;
Auclair, Daniel ;
Li, Liren ;
Place, Chelsea ;
DiCara, Daniel ;
Ramos, Alex H. ;
Lawrence, Michael S. ;
Cibulskis, Kristian ;
Sivachenko, Andrey ;
Voet, Douglas ;
Saksena, Gordon ;
Stransky, Nicolas ;
Onofrio, Robert C. ;
Winckler, Wendy ;
Ardlie, Kristin ;
Wagle, Nikhil ;
Wargo, Jennifer ;
Chong, Kelly ;
Morton, Donald L. ;
Stemke-Hale, Katherine ;
Chen, Guo ;
Noble, Michael ;
Meyerson, Matthew ;
Ladbury, John E. ;
Davies, Michael A. ;
Gershenwald, Jeffrey E. ;
Wagner, Stephan N. ;
Hoon, Dave S. B. ;
Schadendorf, Dirk ;
Lander, Eric S. ;
Gabriel, Stacey B. ;
Getz, Gad ;
Garraway, Levi A. ;
Chin, Lynda .
CELL, 2012, 150 (02) :251-263