Beyond the genome and proteome: targeting protein modifications in cancer

被引：16
作者：
Markiv, Anatoliy [1 ]
Rambaruth, Neela Devi Sing [1 ]
Dwek, Miriam Victoria [1 ]
机构：
[1] Univ Westminster, Sch Life Sci, Dept Mol & Appl Biosci, London W1W 6UW, England
来源：
CURRENT OPINION IN PHARMACOLOGY | 2012年 / 12卷 / 04期
关键词：
O-GLCNAC TRANSFERASE; BREAST-CANCER; GLYCOSYLATION; GLYCANS; MODULATION; PHOSPHORYLATION; GLCNACYLATION; BIOSYNTHESIS; COMPLEX; BINDING;
D O I：
10.1016/j.coph.2012.04.003
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Nearly all proteins are modified in post translational events, indeed, understanding the control and function of post translational modifications (PTMs) is arguably the 'next frontier' for cancer cell biologists. The most well understood PTMs include glycosylation, phosphorylation, ubiquitination, methylation and palmitylation. Each of these modifications has been observed to be altered in cancer, affecting key cellular pathways including signal transduction, cell membrane receptor function, and protein protein interactions. A number of strategies have been proposed that aim to target the modified proteins themselves, the enzymes that construct them, or that boost host-cellular immunity against modified residues aberrantly expressed in cancer.
引用
收藏
页码：408 / 413
页数：6
相关论文
共 47 条
[1]   Evading tumor evasion: Current concepts and perspectives of anti-angiogenic cancer therapy [J].
Abdollahi, Amir ;
Folkman, Judah .
DRUG RESISTANCE UPDATES, 2010, 13 (1-2) :16-28
[2]   Glycans as cancer biomarkers [J].
Adamczyk, Barbara ;
Tharmalingam, Tharmala ;
Rudd, Pauline M. .
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2012, 1820 (09) :1347-1353
[3]   On the frequency of protein glycosylation, as deduced from analysis of the SWISS-PROT database [J].
Apweiler, R ;
Hermjakob, H ;
Sharon, N .
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1999, 1473 (01) :4-8
[4]   Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets [J].
Bedford, Lynn ;
Lowe, James ;
Dick, Lawrence R. ;
Mayer, R. John ;
Brownell, James E. .
NATURE REVIEWS DRUG DISCOVERY, 2011, 10 (01) :29-46
[5]  
Bennett EP., GLYCOBIOLOGY
[6]   Autoantibodies to aberrantly glycosylated MUC1 in early stage breast cancer are associated with a better prognosis [J].
Blixt, Ola ;
Bueti, Deanna ;
Burford, Brian ;
Allen, Diane ;
Julien, Sylvain ;
Hollingsworth, Michael ;
Gammerman, Alex ;
Fentiman, Ian ;
Taylor-Papadimitriou, Joyce ;
Burchell, Joy M. .
BREAST CANCER RESEARCH, 2011, 13 (02)
[7]   Ubiquitin Binding to A20 ZnF4 Is Required for Modulation of NF-κB Signaling [J].
Bosanac, Ivan ;
Wertz, Ingrid E. ;
Pan, Borlan ;
Yu, Christine ;
Kusam, Saritha ;
Lam, Cynthia ;
Phu, Lilian ;
Phung, Qui ;
Maurer, Brigitte ;
Arnott, David ;
Kirkpatrick, Donald S. ;
Dixit, Vishva M. ;
Hymowitz, Sarah G. .
MOLECULAR CELL, 2010, 40 (04) :548-557
[8]   Mucin-type O-glycans in human colon and breast cancer:: glycodynamics and functions [J].
Brockhausen, Inka .
EMBO REPORTS, 2006, 7 (06) :599-604
[9]  
Brooks SA, 2000, HISTOL HISTOPATHOL, V15, P143, DOI 10.14670/HH-15.143
[10]   O-linked glycosylation in the mammary gland: Changes that occur during malignancy [J].
Burchell, JM ;
Mungul, A ;
Taylor-Papadimitriou, J .
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 2001, 6 (03) :355-364
12345