Raman spectroscopy detects distant invasive brain cancer cells centimeters beyond MRI capability in humans

被引：70

作者：

Jermyn, Michael ^{[1
,2
,3
]}

Desroches, Joannie ^{[3
]}

Mercier, Jeanne ^{[3
]}

St-Arnaud, Karl ^{[3
]}

Guiot, Marie-Christine ^{[2
,4
]}

Leblond, Frederic ^{[3
,5
]}

Petrecca, Kevin ^{[2
]}

机构：

[1] Dartmouth Coll, Thayer Sch Engn, 14 Engn Dr, Hanover, NH 03755 USA

[2] McGill Univ, Montreal Neurol Inst & Hosp, Dept Neurol & Neurosurg, 3801 Univ St, Montreal, PQ H3A 2B4, Canada

[3] Polytech Montreal, Dept Engn Phys, CP 6079,Succ Ctr Ville, Montreal, PQ H3C 3A7, Canada

[4] McGill Univ, Dept Pathol, Div Neuropathol, 3801 Univ St, Montreal, PQ H3A 2B4, Canada

[5] Ctr Hosp Univ Montreal, Ctr Rech, 900 Rue St Denis, Montreal, PQ H2X 0A9, Canada

来源：

BIOMEDICAL OPTICS EXPRESS | 2016年 / 7卷 / 12期

基金：

加拿大健康研究院; 加拿大自然科学与工程研究理事会;

关键词：

LOW-GRADE GLIOMAS; GLIOBLASTOMA-MULTIFORME; COHERENCE TOMOGRAPHY; TUMOR TISSUE; RESECTION; EXTENT; FLUORESCENCE; NEURONAVIGATION; RADIOTHERAPY; TEMOZOLOMIDE;

D O I：

10.1364/BOE.7.005129

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Surgical treatment of brain cancer is limited by the inability of current imaging capabilities such as magnetic resonance imaging (MRI) to detect the entirety of this locally invasive cancer. This results in residual cancer cells remaining following surgery, leading to recurrence and death. We demonstrate that intraoperative Raman spectroscopy can detect invasive cancer cells centimeters beyond pathological T1-contrast-enhanced and T2-weighted MRI signals. This intraoperative optical guide can be used to detect invasive cancer cells and minimize post-surgical cancer burden. The detection of distant invasive cancer cells beyond MRI signal has the potential to increase the effectiveness of surgery and directly lengthen patient survival. (C) 2016 Optical Society of America

引用

页码：5129 / 5137

页数：9

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