Selectfluor-promoted Synthesis of 2,4-and 2,6-Diarylpyridines Through Annulation of Aromatic Ketones with an Ammonium Source in DMF

被引：19

作者：

Chen, Jing ^{[1
]}

Ding, Yuxin ^{[1
]}

Gao, Yejun ^{[1
]}

Zhou, Dongheng ^{[1
,3
]}

Hider, Robert ^{[4
]}

Ma, Yongmin ^{[1
,2
]}

机构：

[1] Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China

[2] Taizhou Univ, Sch Pharmaceut & Chem Engn, Taizhou 318000, Peoples R China

[3] Zhejiang Univ, Dept Biochem & Mol Biol, Sch Med, Hangzhou 310058, Zhejiang, Peoples R China

[4] Kings Coll London, Inst Pharmaceut Sci, Franklin Wilkins Bldg,Stamford St, London SE1 9NH, England

来源：

CHEMISTRYSELECT | 2019年 / 4卷 / 08期

关键词：

C-H functionalization; DMF; Selectfluor; pyridines; POLYSUBSTITUTED PYRIDINES; CYCLIZATION; EFFICIENT; QUINOLINES; DMSO; 3-ACETYL-2-AMINOTHIOPHENES; METHYLENATION; DERIVATIVES; COMPLEXES; OXIDATION;

D O I：

10.1002/slct.201900113

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient one-pot four-component condensation and cyclization of ketones with DMF and ammonium acetate for the synthesis of 2,4-diarylsubstituted pyridines promoted by Selectfluor has been achieved. Symmetrical pyridines were obtained selectively when non-methyl ketones were used as the starting materials. Two C-C and C-N bonds are formed during the oxidative cyclization process.

引用

页码：2404 / 2408

页数：5

共 8 条

[1] Simple Selective Synthesis of 2,4-and 2,6-Diarylpyridines through Metal-Free Cyclocondensation of Aromatic Ketones with Ammonium Acetate
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[2] Synthesis of Asymmetrical 2,6-Diarylpyridines from Linear α,β,γ,δ-Unsaturated Ketones by Addition of Ammonium Formate Followed by Annulation
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[8] Dimethyl Sulfoxide Oxygen Donor-Based Annulation of Ketones and Ammonium Persulfate: Regioselective Synthesis of 2,4-disubstituted Oxazoles
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