Current Treatment of Anal Squamous Cell Carcinoma

被引：17

作者：

Glynne-Jones, Rob ^{[1
]}

Renehan, Andrew ^{[2
,3
]}

机构：

[1] Mt Vernon Hosp, Dept Radiotherapy, Ctr Canc Treatment, Northwood HA6 2RN, Middx, England

[2] Christie NHS Fdn Trust, Dept Surg, Manchester M20 4BX, Lancs, England

[3] Univ Manchester, Inst Canc Sci, Manchester M20 4BX, Lancs, England

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2012年 / 26卷 / 06期

关键词：

Squamous cell carcinoma of the anus; Human papilloma virus; Chemoradiotherapy; Salvage surgery; QUALITY-OF-LIFE; DOSE RADIATION-THERAPY; CONTINUOUS-INFUSION; 5-FLUOROURACIL; HUMAN-PAPILLOMAVIRUS INFECTION; COOPERATIVE-ONCOLOGY-GROUP; COMBINED-MODALITY THERAPY; GROWTH-FACTOR RECEPTOR; PHASE-II; MITOMYCIN-C; EPIDERMOID CARCINOMA;

D O I：

10.1016/j.hoc.2012.08.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The primary aim of anal cancer treatment is loco-regional control with preservation of anal function. Phase III trials consistently demonstrate radiotherapy with concurrent 5FU and mitomycin (MMC) chemoradiation is the standard of care for anal cancer. Salvage surgery is associated with considerable morbidity and requires specialised input. With current sophisticated radiological staging and the ability to spare critical normal tissues with intensity-modulated radiotherapy, a "one-size-fits-all" approach is probably inappropriate. Radiotherapy dose-escalation and intensification of the concurrent chemotherapy might improve local control, but may also adversely affect colostomy-free survival. Integration of biologic therapy with conventional chemotherapies looks hopeful in the future.

引用

页码：1315 / +

页数：37

共 177 条

[1] Anal intraepithelial neoplasia [J].

Abbasakoor, F ;

Boulos, PB .

BRITISH JOURNAL OF SURGERY, 2005, 92 (03) :277-290

[2] Intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer [J].

Adelstein, DJ ;

Li, Y ;

Adams, GL ;

Wagner, H ;

Kish, JA ;

Ensley, JF ;

Schuller, DE ;

Forastiere, AA .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (01) :92-98

[3]

AJANI JA, 1989, AM J MED, V87, P221

[4] Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal - A randomized controlled trial [J].

Ajani, Jaffer A. ;

Winter, Kathryn A. ;

Gunderson, Leonard L. ;

Pedersen, John ;

Benson, Al B., III ;

Thomas, Charles R., Jr. ;

Mayer, Robert J. ;

Haddock, Michael G. ;

Rich, Tyvin A. ;

Willett, Christopher .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 299 (16) :1914-1921

[5] Apparent lack of prognostic value of MiB-1 index in anal carcinomas treated by radiotherapy [J].

Allal, AS ;

Alonso-Pentzke, L ;

Remadi, S .

BRITISH JOURNAL OF CANCER, 1998, 77 (08) :1333-1336

[6] Impact of clinical and therapeutic factors on major late complications after radiotherapy with or without concomitant chemotherapy for anal carcinoma [J].

Allal, AS ;

Mermillod, B ;

Roth, AD ;

Marti, MC ;

Kurtz, JM .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1997, 39 (05) :1099-1105

[7] Assessment of long-term quality of life in patients with anal carcinomas treated by radiotherapy with or without chemotherapy [J].

Allal, AS ;

Sprangers, MAG ;

Laurencet, F ;

Reymond, MA ;

Kurtz, JM .

BRITISH JOURNAL OF CANCER, 1999, 80 (10) :1588-1594

[8] Expression of epidermal growth factor receptor in squamous cell carcinomas of the anal canal is independent of gene amplification [J].

Alvarez, Gustavo ;

Perry, Arie ;

Tan, Benjamin R. ;

Wang, Hanlin L. .

MODERN PATHOLOGY, 2006, 19 (07) :942-949

[9]

[Anonymous], NAT COMPR CANC NETW

[10]

[Anonymous], 2000, WHO CLASSIFICATION T

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