Synthesis of pyrido[1,2-a]benzimidazoles and other fused imidazole derivatives with a bridgehead nitrogen atom

被引：16
作者：
Begunov, R. S. [1 ]
Ryzvanovich, G. A. [1 ]
机构：
[1] PG Demidov Yaroslavl State Univ, Ul Sovetskaya 14, Yaroslavl 150000, Russia
来源：
RUSSIAN CHEMICAL REVIEWS | 2013年 / 82卷 / 01期
关键词：
CONDENSED RING-SYSTEMS; POTENTIAL ANXIOLYTIC AGENTS; ONE-POT SYNTHESIS; HETEROATOMIC PHOTOCYCLIZATION; REGIOSELECTIVE SYNTHESIS; HETEROCYCLIC SYNTHESIS; ANTITUMOR-ACTIVITY; FACILE SYNTHESIS; ROUTE; 2-AMINOBENZIMIDAZOLE;
D O I：
10.1070/RC2013v082n01ABEH004295
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Main methods for the synthesis of fused imidazole derivatives with a bridgehead nitrogen atom are systematically considered and summarized. The reaction mechanisms that underlie the methods for the synthesis of pyrido[1,2-a]benzimidazoles and related compounds are described. Biological properties and mechanisms of the biological activity of fused azaheterocycles are discussed. The bibliography includes 152 references.
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页码：77 / 97
页数：21
相关论文
共 157 条
  • [1] Formal [4+2] intramolecular cycloaddition ketenimine-imine.: Synthesis of benzimidazo[1,2-b]isoquinolines
    Alajarín, M
    Vidal, A
    Tovar, F
    Conesa, C
    [J]. TETRAHEDRON LETTERS, 1999, 40 (33) : 6127 - 6130
  • [2] Periselective intramolecular [4+2] cycloadditions of ketenimines:: synthesis of pyrido[1,2-a]benzimidazoles
    Alajarín, M
    Vidal, A
    Tovar, F
    [J]. TETRAHEDRON LETTERS, 2000, 41 (36) : 7029 - 7032
  • [3] Synthesis of pyrazino[1,2-a]benzimidazol-1(2H)ones via a microwave assisted Buchwald-Hartwig type reaction
    Alen, Jo
    Robeyns, Koen
    De Borggraeve, Wim M.
    Van Meervelt, Luc
    Compernolle, Frans
    [J]. TETRAHEDRON, 2008, 64 (35) : 8128 - 8133
  • [4] NOVEL SYNTHESIS OF PYRIDO[1,2-A]BENZIMIDAZOLES VIA REACTION OF N-ACYL ARYLHYDROXYLAMINES WITH PYRIDINE
    ANDERSON, DJ
    TAYLOR, AJ
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1986, 23 (04) : 1091 - 1094
  • [5] Anderson H, 1996, CELL GROWTH DIFFER, V7, P83
  • [6] Anisimova V. A., 2005, Khimiko-Farmatsevticheskii Zhurnal, V39, P17
  • [7] Anisimova V. A., 2005, Khimiko-Farmatsevticheskii Zhurnal, V39, P26
  • [8] Anisimova V. A., 2006, Khimiko-Farmatsevticheskii Zhurnal, V40, P3
  • [9] [Anonymous], 2010, RF P, Patent No. 2394824
  • [10] [Anonymous], 1999, US P., Patent No. 5922731
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