Postoperative circulating tumor DNA detection is associated with the risk of recurrence in patients resected for a stage II colorectal cancer

被引：6

作者：

Grancher, Adrien ^{[1
,2
]}

Beaussire, Ludivine ^{[1
,2
,3
]}

Manfredi, Sylvain ^{[4
]}

Le Malicot, Karine ^{[4
]}

Dutherage, Marie ^{[1
,2
]}

Verdier, Vincent ^{[1
,2
]}

Mulot, Claire ^{[5
]}

Bouche, Olivier ^{[6
]}

Phelip, Jean-Marc ^{[7
]}

Levache, Charles-Briac ^{[8
]}

Deguiral, Philippe ^{[9
]}

Coutant, Sophie ^{[1
,2
]}

Sefrioui, David ^{[1
,2
]}

Emile, Jean-Francois ^{[10
]}

Laurent-Puig, Pierre ^{[11
]}

Bibeau, Frederic ^{[12
]}

Michel, Pierre ^{[1
,2
]}

Sarafan-Vasseur, Nasrin ^{[1
,2
]}

Lepage, Come ^{[4
]}

Di Fiore, Frederic ^{[1
,2
,3
]}

机构：

[1] Normandie Univ, Rouen Univ Hosp, Inserm U1245, UNIROUEN,IRON Grp,Normandy Ctr Genom & Personaliz, Rouen, France

[2] Normandie Univ, Dept Hepatogastroenterol, Rouen, France

[3] Henri Becquerel Ctr, Dept Med Oncol, Rouen, France

[4] Univ Bourgogne Franche Comte, INSERM, Burgundy Digest Canc Registry, Lipides,Nutr,Canc LNC UMR1231, Dijon, France

[5] Paris Univ, Biol Resources Ctr EPIGENETEC, Paris, France

[6] Univ Hosp Reims, Dept Digest Oncol, Reims, France

[7] Univ Hosp St Etienne, Dept Gastroenterol & Digest Oncol, St Etienne, France

[8] Polyclin Francheville, Dept Radiotherapy & Med Oncol, Perigueux, France

[9] St Nazaire Hosp, Dept Gastroenterol, St Nazaire, France

[10] Hop Ambroise Pare, Dept Pathol, Boulogne Billancourt, France

[11] Georges Pompidou Hosp, AP HP, Dept Biol, Paris, France

[12] Caen Univ Hosp, Dept Pathol, Caen, France

来源：

FRONTIERS IN ONCOLOGY | 2022年 / 12卷

关键词：

circulating tumor DNA; liquid biopsy; colorectal cancer; stage II; next generation sequencing; CELL-FREE DNA; COLON-CANCER; ADJUVANT CHEMOTHERAPY; MARKER;

D O I：

10.3389/fonc.2022.973167

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Circulating tumor DNA (ctDNA) is reported to be promising in localized colorectal cancer (CRC). The present study aimed to retrospectively evaluate the impact of ctDNA in patients with a resected stage II CRC from the PROGIGE 13 trial with available paired tumor and blood samples. A group of recurrent patients were matched one-to-one with nonrecurrent patients according to sex, tumor location, treatment sequence, and blood collection timing. CtDNA was analyzed by digital PCR according to NGS of tumors. Disease-free survival (DFS) and overall survival (OS) were analyzed based on ctDNA, and the risks of recurrence and death were determined. A total of 134 patients were included, with 67 patients in each group. At least one alteration was identified in 115/134 tumors. Postoperative ctDNA was detected in 10/111 (9.0%) informative samples and was detected more frequently in the recurrent group (16.7% versus 1.8%; p = 0.02). The median DFS of ctDNA+ versus ctDNA- patients was 16.8 versus 54 months (p = 0.002), respectively, and the median OS was 51.3 versus 69.5 months (p = 0.03), respectively. CtDNA was associated with recurrence (ORa = 11.13, p = 0.03) and death (HRa = 3.15, p = 0.01). In conclusion, the presence of postoperative ctDNA is associated with both recurrence and survival in stage II CRC.

引用

页数：11

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