Concomitant use of insulin glargine and NPH in type I diabetes

In a prospective study on I I patients with Type I diabetes we evaluated the glycaemic control and hypoglycaemic episodes on a combination therapy of "pre-mixed" and glargine insulin. Glycosylated hemoglobin (HbA(1C)), fasting (FPG) and Post Prandial blood glucose (PPG) levels were recorded at baseline and three monthly intervals for a period of 6 months. The mean HbA(1c) reduced from 9.5 to 7.3%, incidence of hypoglycemias from 1.6 to 0.8, mean FPG from 146.5 to 90.4 and mean PPG from 258.4 to 184 over a six-month observation period. This regimen also helps to avoid injection of insulin before lunch so that child's school schedule is minimally disturbed and yet the incidence of hypoglycemia is not increased.