A potent small-molecule inducer of chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells

被引：21
|
作者：
Cho, Tae-Jun [1 ,2 ]
Kim, Jonghoon [3 ]
Kwon, Soon-Keun [1 ,2 ]
Oh, Keunhee [4 ]
Lee, Jeong-ae [5 ]
Lee, Dong-Sup [4 ]
Cho, Jaejin [1 ,2 ]
Park, Seung Bum [3 ,5 ]
机构：
[1] Seoul Natl Univ, Sch Dent, Seoul, South Korea
[2] Seoul Natl Univ, Dent Res Inst, Seoul, South Korea
[3] Seoul Natl Univ, Dept Chem, Seoul, South Korea
[4] Seoul Natl Univ, Coll Med, Dept Biomed Sci, Seoul, South Korea
[5] Seoul Natl Univ, Dept Biophys & Chem Biol, BioMAX Inst, Seoul 151747, South Korea
来源：
CHEMICAL SCIENCE | 2012年 / 3卷 / 10期
基金：
新加坡国家研究基金会;
关键词：
TGF-BETA; PROGENITOR CELLS; CARTILAGE; METASTASIS; MODULATORS; CARCINOMA; ADULT;
D O I：
10.1039/c2sc20362f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We discovered a novel small-molecule modulator 5{i,2} that can specifically induce the chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBM-MSCs). Based on our biochemical and histological studies, 5{i,2} showed more of a directed differentiation of MSCs to chondrocyte balls compared to TGF-beta 3.
引用
收藏
页码：3071 / 3075
页数：5
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