The effect of procyanidine crosslinking on the properties of the electrospun gelatin membranes

被引：17
作者：
Chen, Zhengjian [1 ]
Wang, Liqun [1 ]
Jiang, Hongliang [1 ]
机构：
[1] Zhejiang Univ, Dept Polymer Sci & Engn, Hangzhou 310027, Peoples R China
来源：
BIOFABRICATION | 2012年 / 4卷 / 03期
基金：
美国国家科学基金会;
关键词：
TISSUE ENGINEERING APPLICATIONS; LINKED GELATIN; BIOMEDICAL APPLICATIONS; NANOFIBROUS SCAFFOLDS; TRICALCIUM PHOSPHATE; FIBROUS SCAFFOLDS; DRUG-DELIVERY; PROANTHOCYANIDINS; COLLAGEN; REGENERATION;
D O I：
10.1088/1758-5082/4/3/035007
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In this study, the effect of different crosslinkers including glutaraldehyde (GTA), genipin (GIP) and procyanidine (PA) on the properties of the electrospun gelatin membranes was compared. The water-resistant ability of the membranes could be significantly improved after being crosslinked with PA at T > 40 degrees C. In contrast with GTA and GIP, the PA-crosslinking process did not apparently affect the fibrous structure, and induced the lowest shrinkage of the membranes. At the concentration of 5% of PA, the ultimate tensile strength and elongation of the hydrated membrane were 0.87 MPa and 148%, respectively, which were higher than those of the GIP-crosslinked counterparts. In addition, the PA-crosslinked membranes displayed the highest resistance to pepsin degradation, and fibroblast cells could migrate deeper into the interior of the membranes due to the good preservation of the fibrous structure during the cell culture process.
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页数：11
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