Humoral immune responses of tuberculosis patients in Brazil indicate recognition of Mycobacterium tuberculosis MPT-51 and GlcB

被引：11
作者：
Cardoso Almeida, Cristina Melo [1 ]
Vasconcelos, Arioldo C., Jr. [1 ]
Kipnis, Andre [2 ]
Andrade, Ana Lucia [3 ]
Junqueira-Kipnis, Ana Paula [1 ]
机构：
[1] Univ Fed Goias, Dept Microbiol Immunol Parasitol & Patol, Lab Imunopatol Doencas Infecciosas, Goiania, Go, Brazil
[2] Univ Fed Goias, Lab Bacteriol Mol, Goiania, Go, Brazil
[3] Univ Fed Goias, Dept Saude Coletiva, Inst Patol Trop & Saude Publ, Goiania, Go, Brazil
来源：
CLINICAL AND VACCINE IMMUNOLOGY | 2008年 / 15卷 / 03期
关键词：
D O I：
10.1128/CVI.00359-07
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The humoral responses to recombinant MPT-51 and GlcB was determined by using an enzyme-linked immunosorbent assay. Levels of immunoglobulin M (IgM) against MPT-51 and IgG against GlcB were higher among tuberculosis ( TB) patients than among control individuals. When the MPT-51 and GlcB assays were combined, 90.8% specificity and 75.5% sensitivity were observed. MPT-51 and GlcB were recognized in the humoral responses of Brazilian TB patients.
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页码：579 / 581
页数：3
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