The synthesis and antimycobacterial properties of 4-(substituted benzylsulfanyl)pyridine-2-carboxamides

被引：1

作者：

Klimesova, Vera ^{[1
]}

Herzigova, Petra ^{[1
]}

Palat, Karel ^{[1
]}

Machacek, Milos ^{[1
]}

Stolarikova, Jirina ^{[2
]}

Dahse, Hans-Martin ^{[3
]}

Moellmann, Ute ^{[3
]}

机构：

[1] Charles Univ Prague, Fac Pharm, Dept Inorgan & Organ Chem, Heyrovskeho 1203, Hradec Kralove 50005, Czech Republic

[2] Reg Inst Publ Hlth, Ostrava 70200, Czech Republic

[3] Hans Knoell Inst, Leibniz Inst Nat Prod Res & Infect Biol, D-07745 Jena, Germany

来源：

ARKIVOC | 2012年

关键词：

4-Benzylsulfanyl derivatives; pyridine-2-carboxamides; antimycobacterial activity; cytotoxicity;

D O I：

10.3998/ark.5550190.0013.308

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-(Substituted benzylsulfanyl)pyridine-2-carboxamides 6 were synthesized by a three-step synthesis starting from 4-chloropyridine-2-carboxylic acid and substituted benzyl thiols, with the exception of nitroderivatives. The compounds were evaluated for their anti-TB activity against M. tuberculosis, non-tuberculous mycobacteria (M. kansasii and M. avium), and MDR strains of M. tuberculosis. The activities expressed as the minimum inhibitory concentration (MIC) fall into the range of 8-250 mu mol/L. The substances exhibited similar activities against both sensitive and resistant strains.

引用

页码：90 / 103

页数：14

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