Hemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides

被引：111

作者：

Gautam, Ankur ^{[1
]}

Chaudhary, Kumardeep ^{[1
]}

Singh, Sandeep ^{[1
]}

Joshi, Anshika ^{[1
]}

Anand, Priya ^{[1
]}

Tuknait, Abhishek ^{[1
]}

Mathur, Deepika ^{[1
]}

Varshney, Grish C. ^{[2
]}

Raghava, Gajendra P. S. ^{[1
]}

机构：

[1] CSIR, Inst Microbial Technol, Bioinformat Ctr, Chandigarh 160036, India

[2] CSIR, Inst Microbial Technol, Div Cell Biol & Immunol, Chandigarh 160036, India

来源：

NUCLEIC ACIDS RESEARCH | 2014年 / 42卷 / D1期

关键词：

CELL-PENETRATING PEPTIDES; ANTIMICROBIAL PEPTIDES; THERAPEUTIC PEPTIDES; STRUCTURE PREDICTION; AMINO-ACID; DESIGN; DISSOCIATION; RESOURCE; SERVER;

D O I：

10.1093/nar/gkt1008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hemolytik (http://crdd.osdd.net/raghava/hemolytik/) is a manually curated database of experimentally determined hemolytic and non-hemolytic peptides. Data were compiled from a large number of published research articles and various databases like Antimicrobial Peptide Database, Collection of Antimicrobial Peptides, Dragon Antimicrobial Peptide Database and Swiss-Prot. The current release of Hemolytik database contains similar to 3000 entries that include similar to 2000 unique peptides whose hemolytic activities were evaluated on erythrocytes isolated from as many as 17 different sources. Each entry in Hemolytik provides comprehensive information about a peptide, like its name, sequence, origin, reported function, property such as chirality, types (linear and cyclic), end modifications as well as details pertaining to its hemolytic activity. In addition, tertiary structure of each peptide has been predicted, and secondary structure states have been assigned. To facilitate the scientific community, a user-friendly interface has been developed with various tools for data searching and analysis. We hope, Hemolytik will be useful for researchers working in the field of designing therapeutic peptides.

引用

页码：D444 / D449

页数：6

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