Mechanisms of Thymus Medulla Development and Function

被引：22

作者：

Anderson, Graham ^{[1
]}

Baik, Song ^{[1
]}

Cowan, Jennifer E. ^{[1
]}

Holland, Amanda M. ^{[1
]}

McCarthy, Nicholas I. ^{[1
]}

Nakamura, Kyoko ^{[1
]}

Parnell, Sonia M. ^{[1
]}

White, Andrea J. ^{[1
]}

Lane, Peter J. L. ^{[1
]}

Jenkinson, Eric J. ^{[1
]}

Jenkinson, William E. ^{[1
]}

机构：

[1] Univ Birmingham, Sch Med, MRC, Ctr Immune Regulat,Inst Biomed Res, Birmingham B15 2TT, W Midlands, England

来源：

THYMIC DEVELOPMENT AND SELECTION OF T LYMPHOCYTES | 2014年 / 373卷

基金：

英国医学研究理事会;

关键词：

REGULATORY T-CELLS; PROMISCUOUS GENE-EXPRESSION; LYMPHOID ORGAN DEVELOPMENT; CREST-DERIVED CELLS; LT-BETA-R; EPITHELIAL-CELLS; DENDRITIC CELLS; SELF-TOLERANCE; NEGATIVE SELECTION; LYMPHOTOXIN PATHWAY;

D O I：

10.1007/82_2013_320

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The development of CD4(+) helper and CD8(+) cytotoxic T-cells expressing the alpha beta form of the T-cell receptor (alpha beta TCR) takes place in the thymus, a primary lymphoid organ containing distinct cortical and medullary microenvironments. While the cortex represents a site of early T-cell precursor development, and the positive selection of CD4(+)8(+) thymocytes, the thymic medulla plays a key role in tolerance induction, ensuring that thymic emigrants are purged of autoreactive alpha beta TCR specificities. In recent years, advances have been made in understanding the development and function of thymic medullary epithelial cells, most notably the subset defined by expression of the Autoimmune Regulator (Aire) gene. Here, we summarize current knowledge of the developmental mechanisms regulating thymus medulla development, and examine the role of the thymus medulla in recessive (negative selection) and dominant (T-regulatory cell) tolerance.

引用

页码：19 / 47

页数：29

共 152 条

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