The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

被引：1739
作者：
Merad, Miriam [1 ,2 ,3 ]
Sathe, Priyanka [1 ,2 ]
Helft, Julie [1 ,2 ]
Miller, Jennifer [1 ,2 ]
Mortha, Arthur [1 ,2 ]
机构：
[1] Mt Sinai Sch Med, Dept Oncol Sci, New York, NY 10029 USA
[2] Mt Sinai Sch Med, Inst Immunol, New York, NY 10029 USA
[3] Mt Sinai Sch Med, Tisch Canc Inst, New York, NY 10029 USA
来源：
ANNUAL REVIEW OF IMMUNOLOGY, VOL 31 | 2013年 / 31卷
关键词：
dendritic cells; plasmacytoid dendritic cells; inflammation; innate immunity; adaptive immunity; MHC CLASS-I; HEMATOPOIETIC PROGENITOR CELLS; PERIPHERAL LYMPHOID ORGANS; COLONY-STIMULATING FACTOR; REGULATORY T-CELLS; EPIDERMAL LANGERHANS CELLS; ANTIGEN CROSS-PRESENTATION; LYMPHOTOXIN-BETA-RECEPTOR; TRANSCRIPTION FACTOR E2-2; LEUKEMIA-LIKE SYNDROME;
D O I：
10.1146/annurev-immunol-020711-074950
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Dendritic cells (DCs) form a remarkable cellular network that shapes adaptive immune responses according to peripheral cues. After four decades of research, we now know that DCs arise from a hematopoietic lineage distinct from other leukocytes, establishing the DC system as a unique hematopoietic branch. Recent work has also established that tissue DCs consist of developmentally and functionally distinct subsets that differentially regulate T lymphocyte function. This review discusses major advances in our understanding of the regulation of DC lineage commitment, differentiation, diversification, and function in situ.
引用
收藏
页码：563 / 604
页数：42
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